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ProteomicsMitochondrial mutant Caenorhabditis elegans Proteome
Inhibition of insulin/IGF-1 signaling (IIS) represents a promising avenue for the treatment of mitochondrial diseases, although many of the molecular mechanisms underlying this beneficial effect remain elusive. Here, we investigate the proteomic landscape of Caenorhabditis elegans with severe mitoch...
ORGANISM(S): Caenorhabditis elegans 
2019-02-13 | PXD011851 | Pride
Metabolism Caenorhabditis elegans Insulin signaling Complex i Mitochondria Mitochondrial deficiency Iis 
ProteomicsMitochondrial mutant Caenorhabditis elegans phosphoproteome
Inhibition of insulin/IGF-1 signaling (IIS) represents a promising avenue for the treatment of mitochondrial diseases, although many of the molecular mechanisms underlying this beneficial effect remain elusive. Here, we investigate the phosphoproteomic landscape of Caenorhabditis elegans with severe...
ORGANISM(S): Caenorhabditis elegans 
2019-02-13 | PXD011859 | Pride
Metabolism Caenorhabditis elegans Insulin signaling Complex i Mitochondria Mitochondrial deficiency Iis 
MetabolomicsMulti‐omics identify xanthine as a pro‐survival metabolite for nematodes with mitochondrial dysfunction
Aberrant mitochondrial function contributes to the pathogenesis of various metabolic and chronic disorders. Inhibition of insulin/IGF-1 signaling (IIS) represents a promising avenue for the treatment of mitochondrial diseases, although many of the molecular mechanisms underlying this beneficial effe...
2019-02-28 | MTBLS794 | MetaboLights
ProteomicsActin-nucleation promoting factor N-WASP influences alpha-synuclein condensates and pathology
Abnormal intraneuronal accumulation of soluble and insoluble alpha-synuclein (alpha-Syn) is one of the main pathological hallmarks of synucleinopathies, such as Parkinson’s disease (PD). It has been well- documented that the reversible liquid-liquid phase separation of alpha-Syn can modulate synapti...
ORGANISM(S): Homo Sapiens (human) Caenorhabditis Elegans 
2025-03-22 | PXD050719 | JPOST Repository
ProteomicsMouse multi-organ age-associated protein changes across life stages
Ageing is a key risk factor for disease and mortality in humans and other animals, with most insights derived from genomic, epigenomic, and transcriptomic studies. However, large-scale datasets on age-related changes at the protein level remain scarce. To fill this gap, we performed a comprehensive ...
ORGANISM(S): Mus Musculus (mouse) 
2025-06-17 | PXD058684 | JPOST Repository
ProteomicsThe senescence-associated cell surfaceome reveals potential senotherapeutic targets in human and mouse cells
Excessive accumulation of senescent cells contributes to a wide range of physiological declines and age-related pathologies. Senotherapy targeting senescent cell surface molecules represents an attractive approach to eliminate senescent cells with high specificity and accessibility. However, the com...
ORGANISM(S): Homo Sapiens (human) Mus Musculus (mouse) 
2025-01-26 | PXD048921 | JPOST Repository
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