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TranscriptomicsDiscovery of novel hypermethylated gene loci in prostate cancer using genome wide coverage CpG island microarrays
In order to identify methylation changes in prostate cancer, we performed a genome-wide analysis of DNA methylation using Agilent human CpG island arrays. We then chose specific genes to validate methylation both in the same cases as were hybridized to the array (using quantitative EpiTYPER analysis...
ORGANISM(S): Homo sapiens 
2009-03-26 | E-GEOD-15298 | biostudies-arrayexpress
GenomicsDynamic interplay between locus-specific DNA methylation and hydroxymethylation regulates distinct biological pathways in prostate carcinogenesis
Background: Despite the significant global loss of DNA hydroxymethylation marks in prostate cancer tissues, the locus-specific role of hydroxymethylation in prostate tumorigenesis is unknown. We characterized hydroxymethylation and methylation marks by performing whole-genome next generation sequenc...
ORGANISM(S): Homo sapiens 
2016-03-15 | E-GEOD-74464 | biostudies-arrayexpress
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