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TranscriptomicsMutant IDH inhibits HNF4a to disrupt hepatocyte differentiation and promote cholangiocarcinoma.
Gene expression of mouse hepatoblasts (HBs) expressing IDH1 WT, IDH1 R132C, IDH2 WT, R172K and empty vector controls (N=2 cultures for each condition) grown on collagen-coated plates and IDH1 R132C and empty vector controls on uncoated plates were evaluated using Affymetrix Mouse 430Av2 DNA microarr...
ORGANISM(S): Mus musculus 
2014-04-30 | E-GEOD-57002 | biostudies-arrayexpress
TranscriptomicsRNA-Seq Samples of siTFE3 in 8988T PDA Cell Line to Investigate Transcriptional Control of the Autophagy-Lysosome System
The activation of cellular quality control pathways to maintain metabolic homeostasis and mitigate diverse cellular stresses is emerging as a critical growth and survival mechanism in many cancers. Autophagy, a highly conserved cellular self-degradative process, is a key player in the initiation and...
ORGANISM(S): Homo sapiens 
2015-04-03 | E-GEOD-62077 | biostudies-arrayexpress
ProteomicsMutant GNAS drives pancreatic tumorigenesis by inducing PKA-mediated SIK suppression and reprogramming lipid metabolism
Proteome maps were generated for mouse KGC pancreatic tumor organoid lines expressing doxycycline-inducible constitutively-active mutant GNAS (GNASR201C). The organoids were analyzed in the absence (ctrl) or presence (induced) of doxycycline. Two models, KGC Line-1 (line1) and Line-2 (line2), were a...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2018-04-23 | MSV000082305 | MassIVE
ProteomicsLKB1 loss links serine metabolism to DNA methylation and tumorigenesis
Proteome maps were generated for pancreatic ductal epithelial cells from LSL KRASG12D/+ and LSL KRASG12D/+;LKB1l/l mice. The cells were isolated from the mice, and genetic lesions were induced in vitro by infection with Ade-Cre. Proteome maps were done with multiplexed proteomics using TMT10plex t...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2018-03-20 | MSV000082186 | MassIVE
ProteomicsLiver lineage confers sensitivity of cancer cells to sulfonation-dependent alkylators: PDX and Immobilized Drug Enrichment
The small molecule YC-1 was identified as identified as a selectively active agent against subsets of the two major live cancer subtypes, intrahepatic cholangiocarcinoma and hepatocellular carcinoma. Response to YC-1 is dependent on the expression of the sulfotransferase SULT1A1, which activates YC...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-11-29 | MSV000090808 | MassIVE
ProteomicsLiver lineage confers sensitivity of cancer cells to sulfonation-dependent alkylators: Cell Lines
The small molecule YC-1 was identified as identified as a selectively active agent against subsets of the two major live cancer subtypes, intrahepatic cholangiocarcinoma and hepatocellular carcinoma. Response to YC-1 is dependent on the expression of the sulfotransferase SULT1A1, which activates YC...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-11-29 | MSV000090805 | MassIVE
TranscriptomicsSingle Cell RNA-sequencing of Pancreatic Circulating Tumor Cells
Circulating Tumor Cells (CTCs) are shed from primary tumors into the bloodstream, mediating the hematogenous spread of cancer to distant organs. Using a pancreatic cancer mouse model, we applied a microfluidic device to isolate CTCs independently of tumor epitopes, subjecting these to single cell RN...
ORGANISM(S): Mus musculus 
2014-09-22 | E-GEOD-51372 | biostudies-arrayexpress
ProteomicsFGFR inhibition blocks NF-kappaB-dependent glucose metabolism and confers metabolic vulnerabilities in cholangiocarcinoma
This study explored the response to FGFR inhibition in FGFR2-fusion+ intrahepatic cholangiocarcinoma. We conducted phosphoproteomics experiments in a patient-derived FGFR2-driven ICC cell line model upon FGFR inhibition. Samples were treated with the FGFR inhibitor, Futibatinib/TAS120 (75 nM) for ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-01-24 | MSV000093916 | MassIVE
ProteomicsGeneration of a biliary tract cancer cell line atlas identifies molecular subtypes and therapeutic targets
Biliary tract cancers (BTCs) are lethal malignancies, including intrahepatic and extrahepatic cholangiocarcinoma, gallbladder carcinoma, and ampullary carcinoma. Through multi-omics profiling and CRISPR screens of 63 BTC cell lines, we identify widespread EGFR dependency and subtype-specific vulnera...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2025-03-07 | MSV000097266 | MassIVE
TranscriptomicsRNA sequencing of circulating tumour cells implicates WNT signaling in pancreatic cancer metastasis (mouse data)
Circulating tumour cells (CTCs) shed into blood from primary cancers include putative precursors that initiate distal metastases. While these cells are extraordinarily rare, they may identify cellular pathways contributing to the blood-borne dissemination of cancer. Here, we adapted a microfluidic d...
ORGANISM(S): Mus musculus 
2012-08-17 | E-GEOD-40171 | biostudies-arrayexpress
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