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UnknownTargeted therapy for metastatic triple negative breast cancer: The next frontier in precision oncology.
Not available
S-EPMC5739720 | biostudies-literature
UnknownComparison of the Genomic Landscape Between Primary Breast Cancer in African American Versus White Women and the Association of Racial Differences With Tumor Recurrence.
Not available
S-EPMC4979243 | biostudies-literature
UnknownEfficacy and Safety of Anti-Trop-2 Antibody Drug Conjugate Sacituzumab Govitecan (IMMU-132) in Heavily Pretreated Patients With Metastatic Triple-Negative Breast Cancer.
Not available
S-EPMC5559902 | biostudies-literature
TranscriptomicsCirculating Breast Tumor Cells Exhibit Dynamic Changes in Epithelial and Mesenchymal Cell Composition
By applying RNA-ISH and RNAseq to circulating tumor cells (CTCs), the study provides definitive evidence of epithelial to mesenchymal transition (EMT) across all histological types of breast cancer, identifying mediators such as FOXC1 and TGF-β signaling, and demonstrating dynamic treatment-associat...
ORGANISM(S): Homo sapiens 
2013-02-01 | E-GEOD-41245 | biostudies-arrayexpress
TranscriptomicsHER2 expression identifies dynamic functional states within circulating breast cancer cells
Circulating tumour cells in women with advanced oestrogen-receptor (ER)-positive/human epidermal growth factor receptor 2 (HER2)-negative breast cancer acquire a HER2-positive subpopulation after multiple courses of therapy. In contrast to HER2-amplified primary breast cancer, which is highly sensit...
ORGANISM(S): Homo sapiens 
2016-08-25 | E-GEOD-75367 | biostudies-arrayexpress
TranscriptomicsA microfluidic device for label-free, physical capture of circulating tumor cell-clusters
Cancer cells metastasize through the bloodstream either as single migratory circulating tumor cells (CTCs) or as multicellular groupings (CTC-clusters). Existing technologies for CTC enrichment are designed primarily to isolate single CTCs, and while CTC-clusters are detectable in some cases, their ...
ORGANISM(S): Homo sapiens 
2015-05-17 | E-GEOD-67939 | biostudies-arrayexpress
UnknownRNA-Seq of ex vivo culture of circulating breast tumor cells
Not available
ORGANISM(S): Homo sapiens 
S-ECPF-GEOD-55807 | biostudies-other
TranscriptomicsRNA-Seq of ex vivo culture of circulating breast tumor cells
Analyses of circulating tumor cells (CTC) cultured from blood of patients with cancer may allow individualized testing for susceptibility to therapeutic regimens. We established ex vivo cultures of CTCs from six patients with metastatic estrogen receptor-positive breast cancer and performed RNA-Seq...
ORGANISM(S): Homo sapiens 
2014-07-11 | E-GEOD-55807 | biostudies-arrayexpress
TranscriptomicsCirculating Tumor Cell Clusters are Oligoclonal Precursors of Breast Cancer Metastasis
Clusters of circulating tumor cells (CTC-clusters) are present in the blood of patients with cancer but their contribution to metastasis is not well defined. Here, we first use mouse models to demonstrate that breast cancer cells injected intravascularly as clusters are more prone to survive and col...
ORGANISM(S): Homo sapiens 
2014-07-11 | E-GEOD-51827 | biostudies-arrayexpress
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