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GenomicsBcl6 and NFkB cistromes mediate opposing reulation of the innate immune response
Here, using ChIP-seq, we define the NF-κB cistrome which is comprised of 31,070 cis-acting binding sites responsive to LPS-induced signaling. In addition, we demonstrate that the transcriptional repressor B-cell lymphoma 6 (Bcl-6) regulates nearly a third of the Tlr4-regulated transcriptome and tha...
ORGANISM(S): Mus musculus 
2010-11-24 | E-GEOD-16723 | biostudies-arrayexpress
GenomicsGenome-wide location analysis of SMRT and NCoR in wild-type and Bcl6 knockout macrophages
Using ChIP-seq, we reveal the SMRT and NCoR co-repressor cistromes, which each consist of over 30,000 half-shared binding sites. Moreover, we identify Bcl6-bound sub-cistromes for each co-repressor, which are strongly concentrated on NF-κB-driven inflammatory and tissue remodeling genes. These res...
ORGANISM(S): Mus musculus 
2012-03-29 | E-GEOD-27033 | biostudies-arrayexpress
TranscriptomicsInhibition of Bcl6-SMRT/NCoR interactions by an inhibitory peptide affects inflammatory pathways
Using microarrays, we compared the changes in levels of gene expression between wild type mouse bone marrow derived macrophages upon treatment with the Bcl6 peptide inhibitor, RI-BPI, that specifically blocks interaction between BCL6 and the co-repressors NCoR or SMRT. Total RNA was obtained from cu...
ORGANISM(S): Mus musculus 
2012-03-29 | E-GEOD-27001 | biostudies-arrayexpress
UnknownProspects for observing and localizing gravitational-wave transients with Advanced LIGO, Advanced Virgo and KAGRA.
Not available
S-EPMC5920066 | biostudies-literature
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