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ProteomicsDiscovery of a Small Molecule Secreted Clustering Enhancer that Improves Moemory in Alzheimer's Disease Mice
Here, we present findings from our drug discovery program to identify small molecules that enhance sCLU levels and assess their impact on AD pathology and cognition in a murine model of AD. A high-throughput screening campaign identified two classes of epigenetic modulators that increase sCLU levels...
ORGANISM(S): Mus musculus (Mouse) 
2026-03-30 | PXD060173 | Pride
Epigenetic modulator Alzheimer's disease Memory improvement Secreted clustering enhancer 
MetabolomicsComparative Metabolomic Sampling of Upper and Lower Airways by Four Different Methods to Identify Biochemicals That May Support Bacterial Growth
Bacteria need nutrients from the host environment to survive, yet we know little about which biochemicals are present in the airways (the metabolome), which of these biochemicals are essential for bacterial growth and how they change with airway disease. The aims of this pilot study were to develop ...
2019-06-13 | MTBLS179 | MetaboLights
UnknownExchange Bias in Magnetic Topological Insulator Superlattices.
Not available
S-EPMC7467763 | biostudies-literature
TranscriptomicsImmune cells direct epithelial maturation during early human lung development
The adult human lung harbours a significant proportion of immune cells, which are known to play a crucial role in both normal lung homeostasis and pathogenesis. In this work, we collected CD45-enriched human lung cells from 6 to 22 week post conception (pcw) and built a single-cell transcriptome and...
ORGANISM(S): Homo sapiens 
2022-12-09 | E-MTAB-11528 | biostudies-arrayexpress
UnknownTemperate seaweeds Himanthalia elongata and Fucus vesiculosus significantly reduce rumen methane emissions in vitro due to their high phlorotannin content.
Not available
S-EPMC12439089 | biostudies-literature
UnknownKi67 Proliferation Index as a Tool for Chemotherapy Decisions During and After Neoadjuvant Aromatase Inhibitor Treatment of Breast Cancer: Results From the American College of Surgeons Oncology Group Z1031 Trial (Alliance).
Not available
S-EPMC5455353 | biostudies-literature
TranscriptomicsRNA-sequencing of the small-RNA transcriptome in blood, across three time-points in severe psoriasis patients treated with the tumor necrosis factor (TNF) inhibitor, etanercept
Blood (mRNA and miRNA) and skin mRNA transcriptomes were investigated across three time-points in a pilot investigation of ten severe psoriasis patients, treated with the tumor necrosis factor (TNF) inhibitor, etanercept. We used illumina RNA-sequencing to analyse the small-RNA transcriptome in bloo...
ORGANISM(S): Homo sapiens 
2018-09-21 | E-MTAB-6428 | biostudies-arrayexpress
TranscriptomicsRNA-sequencing of the mRNA transcriptome in lesional and non-lesional skin, across three time-points in severe psoriasis patients treated with the tumor necrosis factor (TNF) inhibitor, etanercept
Blood (mRNA and miRNA) and skin mRNA transcriptomes were investigated across three time-points in a pilot investigation of ten severe psoriasis patients, treated with the tumor necrosis factor (TNF) inhibitor, etanercept. We used illumina RNA-sequencing to analyse the small-RNA transcriptome in bloo...
ORGANISM(S): Homo sapiens 
2018-09-21 | E-MTAB-6556 | biostudies-arrayexpress
TranscriptomicsRNA-sequencing of the mRNA transcriptome in blood, across three time-points in severe psoriasis patients treated with the tumor necrosis factor (TNF) inhibitor, etanercept
Blood (mRNA and miRNA) and skin mRNA transcriptomes were investigated across three time-points in a pilot investigation of ten severe psoriasis patients, treated with the tumor necrosis factor (TNF) inhibitor, etanercept. We used illumina RNA-sequencing to analyse the mRNA transcriptome in blood
ORGANISM(S): Homo sapiens 
2018-10-01 | E-MTAB-6555 | biostudies-arrayexpress
UnknownDistortions to Passage of Time Judgements (POTJ) due to virtual threat are predicted by autonomic activation.
Not available
S-EPMC11620600 | biostudies-literature
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