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GenomicsModulation of enhancer looping and differential gene targeting by Epstein-Barr virus transcription factors directs epigenetic reprogramming
Epstein-Barr virus (EBV) epigenetically reprogrammes B-lymphocytes to drive immortalization and facilitate viral persistence. Host-cell transcription is perturbed principally through the actions of EBV EBNA 2, 3A, 3B and 3C, with cellular genes deregulated by specific combinations of these EBNAs thr...
ORGANISM(S): Homo sapiens 
2013-09-13 | E-GEOD-47629 | biostudies-arrayexpress
TranscriptomicsEpstein-Barr virus maintains lymphomas via its miRNAs
EpsteinM-bM-^@M-^PBarr virus (EBV) has evolved exquisite controls over its host cells, human B lymphocytes, not only directing these cells during latency to proliferate and thereby expand the pool of infected cells, but also to survive and thereby persist for the lifetime of the infected individual....
ORGANISM(S): Homo sapiens 
2013-04-30 | E-GEOD-44769 | biostudies-arrayexpress
TranscriptomicsThe NRF2-KEAP1 pathway is an early responsive gene network in arsenic exposed lymphoblastoid cells
Inorganic arsenic, a major environmental contaminant, has risen as an important health problem worldwide. More detailed identification of the molecular mechanisms associated with iAs exposure would help to establish better strategies for prevention and treatment. Although chronic iAs exposures have ...
ORGANISM(S): Homo sapiens 
2013-10-24 | E-GEOD-51454 | biostudies-arrayexpress
TranscriptomicsAGS cells infected with Epstein Barr Virus
Gene expression profile of AGS gastric carcinoma cell line infected in vitro with Epstein-Barr Virus. Some samples also contain are stably transfected with a dominant negative LMP1 construct. 8 total samples. 4 biological replicates of EBV infected cells, 2 biological replicates with EBV infected ...
ORGANISM(S): Homo sapiens 
2012-05-07 | E-GEOD-37753 | biostudies-arrayexpress
TranscriptomicsAlteration of microRNA gene expression by EBV encoded LMP1 oncogene
The Epstein Barr virus (EBV) encoded latent membrane protein-1 (LMP1) is a functional homologue of the tumor necrosis factor receptor family and contributes substantially to the oncogenic potential of EBV through activation of Nuclear Factor-kappaB (NF-kappaB). MicroRNAs (miRNAs) are a class of smal...
ORGANISM(S): Homo sapiens 
2010-05-26 | E-GEOD-10105 | biostudies-arrayexpress
TranscriptomicsThe viral and cellular microRNA targetome in lymphoblastoid cell lines
Epstein-Barr virus (EBV) is a human herpesvirus linked to a number of B cell cancers and lymphoproliferative disorders. During latent infection, EBV expresses 25 viral pre-microRNAs (miRNAs) and induces the expression of specific host miRNAs, such as miR-155 and miR-21, which potentially play a role...
ORGANISM(S): Homo sapiens 
2012-10-16 | E-GEOD-41437 | biostudies-arrayexpress
TranscriptomicsThe effects of LH ablation/replacement versus steroid ablation/replacement on gene expression in primate corpora lutea
This study was designed to provide a genome-wide analysis of the effects of luteinizing hormone (LH) ablation/replacement versus steroid ablation/replacement on gene expression in the developed corpus luteum (CL) in primates during the menstrual cycle. Naturally cycling, female rhesus monkeys were l...
ORGANISM(S): Macaca mulatta 
2009-01-25 | E-GEOD-12281 | biostudies-arrayexpress
TranscriptomicsmicroRNA Targetome Analysis of Latently KSHV-infected Primary Effusion Lymphoma Cell lines Using PAR-CLIP [Illumina]
Primary effusion lymphoma (PEL) is caused by Kaposi's sarcoma-associated herpesvirus (KSHV) and frequently also harbors Epstein-Barr virus (EBV). The expression of KSHV- and, often, EBV-encoded microRNAs (miRNAs) in PELs suggests a role for these miRNAs in viral latency and lymphomagenesis. Here we ...
ORGANISM(S): Homo sapiens 
2011-11-16 | E-GEOD-32109 | biostudies-arrayexpress
UnknownSubstrate-triggered formation and remarkable stability of the C-H bond-cleaving chloroferryl intermediate in the aliphatic halogenase, SyrB2.
Not available
S-EPMC2684568 | biostudies-literature
TranscriptomicsComparing proteomics and RISC immunoprecipitations to identify targets of Epstein-Barr viral miRNAs [RISC-IP-seq]
Epstein-Barr virus is a gamma-herpes virus that is causally associated with several lymphomas and carcinomas. This virus encodes at least 25 pre-miRNAs, which are expressed in infected cells to yield more than 50 detected mature miRNAs. miRNAs are small, non-coding RNAs that inhibit gene expression ...
ORGANISM(S): Homo sapiens 
2013-05-01 | E-GEOD-46514 | biostudies-arrayexpress
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