The NRF2-KEAP1 pathway is an early responsive gene network in arsenic exposed lymphoblastoid cells

ABSTRACT: Inorganic arsenic, a major environmental contaminant, has risen as an important health problem worldwide. More detailed identification of the molecular mechanisms associated with iAs exposure would help to establish better strategies for prevention and treatment. Although chronic iAs exposures have been previously studied there is little to no information regarding the early events of exposure to iAs. To better characterize the early mechanisms of iAs exposure we conducted gene expression studies using sublethal doses of iAs at two different time-points. The major transcripts differentially regulated at 2 hrs of iAs exposure included antioxidants, detoxificants and chaperones. Moreover, after 12 hrs of exposure many of the down-regulated genes were associated with DNA replication and S pha

ORGANISM(S): Homo sapiens

SUBMITTER: Angelica Martinez 

PROVIDER: E-GEOD-51454 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress