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GenomicsEpstein Barr Virus Nuclear Antigen 3C binds to BATF/IRF4/SPI1 sites and represses CDKN2A by recruiting Sin3A
We report the application of ChIP Seq to study the Epstein Barr Virus Nuclear Antigen 3C, an essential transcriptional regulator involved in the transformation of Resting B Lymphocytes to the immortalized Lymphoblast Cell Lines Examination of viral and cellular transcription factors in 1 type of cel...
ORGANISM(S): Homo sapiens 
2013-12-22 | E-GEOD-52632 | biostudies-arrayexpress
TranscriptomicsEpstein Barr virus Nuclear Antigen 3C regulated genes in Lymphoblastoid Cell Lines
Epstein Barr virus (EBV) nuclear antigen 3C (EBNA3C) is an essential transcription factor for initiating and maintaining human B lymphocyte transformation to lymphoblastoid cell lines (LCLs). To comprehensively identify EBNA3C regulated cell genes in LCLs, oligonucleotide arrays were used to compare...
ORGANISM(S): Homo sapiens 
2011-01-06 | E-GEOD-24362 | biostudies-arrayexpress
GenomicsGenomic landscape of Epstein-Barr virus nuclear antigen 3A
We undertook ChIP-Seq of HA-tagged EBNA3A in Lymphoblastoid Cell Lines to understand the effects of this essential viral transcription factor on the cell DNA. We discovered that EBNA3A bound to DNA with BATF, IRF4 and RUNX3, making these Transcription Factors the ones that tether EBNA3A to DNA, allo...
ORGANISM(S): Homo sapiens 
2015-01-06 | E-GEOD-59181 | biostudies-arrayexpress
TranscriptomicsLai_CME_L1cell_V126
modENCODE_submission_4785 This submission comes from a modENCODE project of Eric Lai. For full list of modENCODE projects, see http://www.genome.gov/26524648 Project Goal: We plan to generate a comprehensive catalog of expressed and functional microRNAs, and generate biological evidence for their re...
ORGANISM(S): Drosophila melanogaster 
2012-04-18 | E-GEOD-37297 | biostudies-arrayexpress
TranscriptomicsLai_S3cell_V074/BS23
modENCODE_submission_4771 This submission comes from a modENCODE project of Eric Lai. For full list of modENCODE projects, see http://www.genome.gov/26524648 Project Goal: We plan to generate a comprehensive catalog of expressed and functional microRNAs, and generate biological evidence for their re...
ORGANISM(S): Drosophila melanogaster 
2012-04-18 | E-GEOD-37291 | biostudies-arrayexpress
UnknownEfficacy of bendamustine and rituximab in unfit patients with previously untreated chronic lymphocytic leukemia. Indirect comparison with ibrutinib in a real-world setting. A GIMEMA-ERIC and US study.
Not available
S-EPMC7666748 | biostudies-literature
UnknownA patient-derived T cell lymphoma biorepository uncovers pathogenetic mechanisms and host-related therapeutic vulnerabilities.
Not available
S-EPMC12047492 | biostudies-literature
TranscriptomicsRNA-seq comparing transcriptome of lymphoblastic cells from FAME patients and control individuals
RNAseq was performed for 10 individuals: three affected individuals (CSDN4, CSDN5, CSDN6) and one healthy spouse (CSDN7) from Family 1, three affected individuals (CSDN1, CSDN2, CSDN3) from Family 5 and three healthy controls (CSDN8, CSDN9, CSDN10).
ORGANISM(S): Homo sapiens 
2019-09-16 | E-MTAB-8301 | biostudies-arrayexpress
TranscriptomicsDivergent influence of microRNA-21 deletion on murine colitis phenotypes [mRNA]
Background: MicroRNAs (miRNAs) acting as negative regulators of gene expression are differentially expressed in intestinal tissues of patients with inflammatory bowel disease (IBD). Assessing the functional role of miRNAs in murine models of colitis facilitates elucidating the role of specific miRN...
ORGANISM(S): Mus musculus 
2014-07-23 | E-GEOD-59648 | biostudies-arrayexpress
TranscriptomicsRNA-seq of 8hr LPS-stimulated bone marrow-derived macrophages from wild type, Ch25h-deficient, and LXRab knockout mice
25-hydroxycholesterol has been demonstrated to regulate SREBP processing, yet Ch25h-deficient mice have no cholesterol abnormalities. Using RNA-seq, we find that LPS-stimulated, Ch25h-deficient BMDMs have dysregulated SREBP target genes, demonstrating that 25-hydroxycholesterol is an induced repres...
ORGANISM(S): Mus musculus 
2014-08-08 | E-GEOD-58993 | biostudies-arrayexpress
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