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MetabolomicsCeramide Promotes Lytic Reactivation of Epstein-Barr Virus in Gastric Carcinoma
Epstein-Barr virus (EBV) has a lifelong latency period after initial infection. Rarely, however, when the EBV immediate early gene BZLF1 is expressed by a specific stimulus, the virus switches to the lytic cycle to produce progeny viruses. We found that EBV infection reduced levels of various cerami...
2023-12-20 | MTBLS7649 | MetaboLights
GenomicsModulation of enhancer looping and differential gene targeting by Epstein-Barr virus transcription factors directs epigenetic reprogramming
Epstein-Barr virus (EBV) epigenetically reprogrammes B-lymphocytes to drive immortalization and facilitate viral persistence. Host-cell transcription is perturbed principally through the actions of EBV EBNA 2, 3A, 3B and 3C, with cellular genes deregulated by specific combinations of these EBNAs thr...
ORGANISM(S): Homo sapiens 
2013-09-13 | E-GEOD-47629 | biostudies-arrayexpress
GenomicsGenomic landscape of Epstein-Barr virus nuclear antigen 3A
We undertook ChIP-Seq of HA-tagged EBNA3A in Lymphoblastoid Cell Lines to understand the effects of this essential viral transcription factor on the cell DNA. We discovered that EBNA3A bound to DNA with BATF, IRF4 and RUNX3, making these Transcription Factors the ones that tether EBNA3A to DNA, allo...
ORGANISM(S): Homo sapiens 
2015-01-06 | E-GEOD-59181 | biostudies-arrayexpress
TranscriptomicsThe EBV latent membrane protein 1 (LMP1) induces cellular microRNA-146a, a modulator of lymphocyte signaling pathways
This SuperSeries is composed of the following subset Series: GSE10057: The Epstein-Barr Virus latent membrane protein 1 (LMP1) induces cellular microRNA146a GSE10105: Alteration of microRNA gene expression by EBV encoded LMP1 oncogene Keywords: SuperSeries Refer to individual Series
ORGANISM(S): Homo sapiens 
2008-01-08 | E-GEOD-10107 | biostudies-arrayexpress
GenomicsEpstein-Barr Virus oncoprotein super-enhancers control B cell growth
Super-enhancers are principal determinants of cell transcription, development, phenotype, and oncogenesis, not yet implicated in host-pathogen interactions. We found four Epstein-Barr virus (EBV) oncoproteins and five EBV-activated NF-M-oM-^AM-+B subunits co-occupying thousand of enhancer sites in E...
ORGANISM(S): Homo sapiens 
2014-11-01 | E-GEOD-62912 | biostudies-arrayexpress
TranscriptomicsTo screen miRNA expression of SP and MP cells in mutiply myeloma by miRNA array
To better understand the molecular mechanisms of SP cells, we screened the miRNAs expression patterns in the SP compared with the MP cells. MiRCURYâ„¢ LNA array analysis of sorted SP and MP cells from two relapsed myeloma patients with more than 70% bone marrow plasma cells were performed. In order ...
ORGANISM(S): Homo sapiens 
2015-12-31 | E-GEOD-56163 | biostudies-arrayexpress
TranscriptomicsHigh salt primes a specific activation state of macrophages, M(Na)
Purpose: Investigate effects of high salt on human macrophage activation Methods: Human monocytes-derived macrophages were treated by additional 51mM NaCl for 24 hours (NaCl groups) or not (Control groups). mRNA profiles were generated by RNA-Seq, in triplicate, using Ion proton（Life tech). qRT–PCR ...
ORGANISM(S): Homo sapiens 
2015-09-23 | E-GEOD-68482 | biostudies-arrayexpress
TranscriptomicsAlteration of microRNA gene expression by EBV encoded LMP1 oncogene
The Epstein Barr virus (EBV) encoded latent membrane protein-1 (LMP1) is a functional homologue of the tumor necrosis factor receptor family and contributes substantially to the oncogenic potential of EBV through activation of Nuclear Factor-kappaB (NF-kappaB). MicroRNAs (miRNAs) are a class of smal...
ORGANISM(S): Homo sapiens 
2010-05-26 | E-GEOD-10105 | biostudies-arrayexpress
ProteomicsErythrocytes lacking the Langereis blood group protein ABCB6 are resistant to Plasmodium falciparum malaria parasites
Epstein Barr virus (EBV) replication contributes to multiple human diseases, including infectious mononucleosis, nasopharyngeal carcinoma, B-cell lymphomas, and oral hairy leukoplakia. We performed systematic quantitative analyses of temporal changes in host and EBV proteins during lytic replication...
ORGANISM(S): Homo sapiens (Human) 
2018-10-19 | PXD008752 | Pride
Human Lc-msmsms Malaria Host-pathogen interaction Quantitative proteomics Tandem mass tag 
UnknownTranscriptome-wide analysis of alternative RNA splicing events in Epstein-Barr virus-associated gastric carcinomas.
Not available
S-EPMC5426614 | biostudies-literature
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