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Transcriptomicsgene expression profiles of Barrett's esophagus, squamous esophagus and gastric cardia
SAGE performed on biopsies of Barrett's esophagus, squamous esophagus and gastric cardia taken from a metaplastic Barrett's esophagus patient. Keywords: SAGE comparative analysis of gene expression profiles of Barrett's esophagus, normal squamous esophagus and gastric cardia tissue
ORGANISM(S): Homo sapiens 
2005-06-20 | E-GEOD-2769 | biostudies-arrayexpress
TranscriptomicsWhole transcriptome profiling of Esophageal adenocarcinoma and Barrett's
RNA-seq was performed on esophageal adenocarcinoma (EAC), Barrett's without dysplasia, Barrett's with low-grade dysplasia (LGD) and normal squamous esophagus tissue to find early alterations in the transcriptome level turning Barrett's dysplastic.
ORGANISM(S): Homo sapiens 
2017-07-23 | E-MTAB-4054 | biostudies-arrayexpress
TranscriptomicsUsing DNA methylation to detect dysplasia/early neoplasia in Barrett's carcinogenesis
Dysplasia and early cancer are hard to detect in endoscopic biopsies and hence this study was carried out to evaluate the biomarker potential of DNA methylation to detect dyspasia and early cancer in Barrett's esophaghus patients. Bisulfite converted genomic DNA was hybridized onto Illumina 27k meth...
ORGANISM(S): Homo sapiens 
2013-01-28 | E-GEOD-32925 | biostudies-arrayexpress
TranscriptomicsWhole genome expression array profiling highlights differences in mucosal defense genes in Barrett's esophagus and esophageal adenocarcinoma.
Esophageal adenocarcinoma (EAC) has become a major concern in Western countries due to rapid rises in incidence coupled with very poor survival rates. One of the key risk factors for the development of this cancer is the presence of Barrett’s esophagus (BE), which is believed to form in response to ...
ORGANISM(S): Homo sapiens 
2011-08-16 | E-GEOD-28302 | biostudies-arrayexpress
TranscriptomicsATAC-seq of human Barrett's oesophagus tissue
Barrett's esophagus is the assumed precusor to oesophageal adenocarcinoma. We profiled the open chromatin of human Barrett's biopsies to gain insight into its molecular basis.
ORGANISM(S): Homo sapiens 
2019-02-04 | E-MTAB-6751 | biostudies-arrayexpress
TranscriptomicsmiR-223 in esophageal adenocarcinoma carcinogenesis
miR-223 is step-wise increasingly up-regulated in the normal esophagus - Barrett's esophagus -esophageal adenocarcinoma carcinoma sequence. In this study, we aimed to determine the function of miR-223 in esophageal adenocarcinoma carcinogenesis. miR-223 was transfected in OE33 cells using 10nM pre-m...
ORGANISM(S): Homo sapiens 
2013-02-07 | E-GEOD-44120 | biostudies-arrayexpress
TranscriptomicsBarrett's esophagus
Barrett's esophagus transcriptome was analysed and compared with Barrett's esophagus primary cell culture and esophageal adenocarcinoma. Keywords: SAGE analysis to compare tissues Barrett's esophagus biopsy was taken from 1 male metaplastic Barrett's esophagus patient. Barrett's esophagus primary ce...
ORGANISM(S): Homo sapiens 
2006-06-28 | E-GEOD-5155 | biostudies-arrayexpress
TranscriptomicsMolecular defense mechanisms of Barrett's metaplasia estimated by an integrative genomics
Barrett's esophagus is characterized by the replacement of squamous epithelium with specialized intestinal metaplastic mucosa. The exact mechanisms of initiation and development of Barrett's metaplasia remain unknown, but a hypothesis of successful adaptation against noxious reflux components has be...
ORGANISM(S): Homo sapiens 
2012-03-08 | E-GEOD-36223 | biostudies-arrayexpress
TranscriptomicsCopy number variation analysis of human Barrett's esophagus stem cells (HumanOmniZhongHua-8 v1.1 Beadchip)
Barrett’s esophagus confers significant risk of esophageal adenocarcinoma. We have established the cloning system of patient-matched stem cells of Barrett’s esophagus and gastric cardia. Barrett's esophagus (BE) stem cells and gastric cardia (GC) stem cells from 12 patients were cloned. To ana...
ORGANISM(S): Homo sapiens 
2016-01-13 | E-GEOD-68663 | biostudies-arrayexpress
TranscriptomicsGene expression profile in Barrett's esopahgus
Microarray was used to identify differential gene expression pattern in Barrett's esophagus (BE), compared to the normal adjacent epithelia gastric cardia (GC) and normal squamous esophagus (NE) RNA was extraxted from endoscopic biopsies of BE (n=10), GC (n=10) and NE (n=10, only 8 uploaded). One N...
ORGANISM(S): Homo sapiens 
2012-03-29 | E-GEOD-34619 | biostudies-arrayexpress
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