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TranscriptomicsPRPF8 CLIP seq for iPSC, kidney organoid, retinal organoid, and retinal epithelium derived from c.6926A>C RPE with Retinitis Pigmentosa patients and CRISPR/Cas9 corrected
Retinitis Pigmentosa is a group of inherited eye disorders characterized by progressive degeneration of photoreceptor cells in the retina, leading to vision loss and eventual blindness. One of the known genetic mutations associated with RP is the c.6926A>C mutation in the RPE (retinal pigment epithe...
ORGANISM(S): Homo sapiens 
2024-03-13 | E-MTAB-13171 | biostudies-arrayexpress
MetabolomicsSymptomatology and Serum Nuclear Magnetic Resonance Metabolomics; Do They Predict Endometriosis in Fertile Women Undergoing Laparoscopic Sterilisation? A Prospective Cross-sectional Study
Endometriosis is a common, chronic inflammatory condition, thought to have a higher incidence in symptomatic women, yet, commonly associated symptoms do not always correlate with the presence or severity of disease and diagnosis requires surgery. We prospectively collected data and assessed symptomo...
2023-05-26 | MTBLS2040 | MetaboLights
Transcriptomics18F-fluorodeoxy-glucose positron emission tomography marks MYC-overexpressing human basal-like breast cancers.
Fluorine-18-fluoro-2-deoxy-D-glucose (FDG) is widely used as positron-emission-tomography (PET) radiotracer for the detection and staging of human cancer. Tumor uptake of FDG varies substantially between different cancer types and between patients with the same tumor type. The molecular basis for th...
ORGANISM(S): Homo sapiens 
2011-11-01 | E-GEOD-21217 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of mouse E15.5 FACS sorted pancreas populations based on double fluorescent reporter (Hes1GFP and Neurog3-RFP), DBA staining and Ptf1a-YFP.
In order to generate a comprehensive map of differentially expressed genes in embryonic mouse pancreas cell types on which to map results from later analyses, we first performed microarray-based gene expression profiling of purified E15.5 pancreas cell populations. We isolated GFP+RFP−DBA+, GFP+RFP+...
ORGANISM(S): Mus musculus 
2018-09-10 | E-MTAB-6891 | biostudies-arrayexpress
TranscriptomicsWhole-genome microarray analysis of human skin fibroblasts
Connective tissue growthfactor (CTGF/CCN2) is a matricellular protein induced by transforming growth factor-beta (TGF-beta) and intimately involved with tissue repair and overexpressed in various fibrotic conditions. We have previously shown that keratinocytes in vitro downregulate TGF-beta induced ...
ORGANISM(S): Homo sapiens 
2016-04-14 | E-GEOD-69447 | biostudies-arrayexpress
TranscriptomicsRiboSeq of BSR cells infected at MOI 3 with Theiler's murine encephalomyelitis virus, compared to mock-infected controls, harvested at 10 hpi
BSR cells were infected with the Cardiovirus B archetype, Theiler’s murine encephalomyelitis virus (TMEV), and mutants thereof, and subjected to ribosome profiling to analyse the viral translatome, frameshifting, and ribosome pausing events. Samples were harvested at 10 hpi by flash-freezing, withou...
ORGANISM(S): Mesocricetus auratus 
2021-11-10 | E-MTAB-9438 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of mouse back skin of wild type and Range knockout animals after aceton treatment.
In order to identify critical changes in the genetic network of Rage signaling induced by TPA throughout a 48 h kinetic, global gene expression analysis was performed. Total RNA from untreated, 24h acetone- and 6, 12, 24, 48 h TPA-treated wt and Rage KO back skin was prepared (n=3 independent animal...
ORGANISM(S): Mus musculus 
2010-11-29 | E-MTAB-205 | biostudies-arrayexpress
GenomicsFunctional Evolution of the Yap/Yorkie Proto-oncogene and Elucidation of its Core Transcriptional Program
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Drosophila melanogaster 
2014-03-01 | E-GEOD-54603 | biostudies-arrayexpress
TranscriptomicsGene expression in the early spinal cord of mice lacking Munc18-1 (STXBP1)
The aim of this experiment was to determine the influence of early spinal circuit activity upon gene expression in the mouse spinal cord by comparing mRNA expression between wild-type and Munc18-1 null mice (Verhage et al., Science, 2000). RNA was extracted from the lumbar spinal cords of 4 wild-typ...
ORGANISM(S): Mus musculus 
2016-05-08 | E-MTAB-3559 | biostudies-arrayexpress
TranscriptomicsMultiple oxygen tension environments reveal diverse patterns of transcriptional regulation in primary astrocytes
The central nervous system normally functions at O2 levels which would be regarded as hypoxic by most other tissues. However, most in vitro studies of neurons and astrocytes are conducted under hyperoxic conditions without consideration of O2-dependent cellular adaptation. We analyzed the reactivi...
ORGANISM(S): Rattus norvegicus 
2012-09-20 | E-GEOD-29296 | biostudies-arrayexpress
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