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MetabolomicsSex-specific effects of CD248 on metabolism and the adipose tissue lipidome

Cd248 has recently been associated with adipose tissue physiology, demonstrated by reduced weight gain in high fat diet-fed mice with genetic deletion of Cd248 relative to controls. Here we set out to determine the metabolic consequences of loss of Cd248. Strikingly, we find these to be sex speci...

2023-01-05 | MTBLS6615 | MetaboLights
TranscriptomicsTranslational activation of developmental mRNAs during neonatal mouse testis development
The sequence of gene regulatory events that drive neonatal germ cell development in the mammalian testis is not yet clear. We assessed changes in mRNA utilization in the neonatal testis at 1 and 4 dpp, times when the testis contains quiescent gonocytes (1 dpp) and proliferating spermatogonia (4 dpp)...
ORGANISM(S): Mus musculus 
2013-07-27 | E-GEOD-49283 | biostudies-arrayexpress
TranscriptomicsPromoter proximal pausing and its regulation by c-Myc in embryonic stem cells: ChIP-chip
Recruitment of the RNA Polymerase II (Pol II) transcription initiation apparatus to promoters by specific DNA binding transcription factors is well recognized as a key regulatory step in gene expression. We describe here evidence that promoter-proximal pausing is a general feature of transcription ...
ORGANISM(S): Mus musculus 
2010-04-02 | E-GEOD-20529 | biostudies-arrayexpress
TranscriptomicsDNA methylation in marmoset primed and naive pluripotent stem cells, and trophoblast stem cells
Bisulfite sequencing on bulk populations of marmoset naïve pluripotent stem cells (PSC), primed PSC, and trophoblsat stem cells.
ORGANISM(S): Callithrix jacchus 
2024-11-21 | E-MTAB-12453 | biostudies-arrayexpress
TranscriptomicsTracing the emergence of primordial germ cells from bilaminar disc rabbit embryos and pluripotent stem cells (bulk RNA-sequencing)
Rabbit embryos, as in humans, develop as bilaminar discs at gastrulation and unlike egg cylinders as in rodents. Mammalian primordial germ cells (PGCs) in all species originate during gastrulation. We sequence the transcriptomes of rabbit embryos during gastrulation, and show that rabbit PGC (rbPGC...
ORGANISM(S): Oryctolagus cuniculus 
2021-10-14 | E-MTAB-10892 | biostudies-arrayexpress
TranscriptomicsA library of yeast transcription factor motifs
The sequence specificity of DNA-binding proteins is the primary mechanism by which the cell recognizes genomic features. Here, we describe systematic determination of yeast transcription factor DNA-binding specificities. We obtained binding specificities for 112 DNA-binding proteins representing 19 ...
ORGANISM(S): Saccharomyces cerevisiae 
2008-12-26 | E-GEOD-12349 | biostudies-arrayexpress
TranscriptomicsPromoter proximal pausing and its regulation by c-Myc in embryonic stem cells
This SuperSeries is composed of the following subset Series: GSE20529: Promoter proximal pausing and its regulation by c-Myc in embryonic stem cells: ChIP-chip GSE20530: Promoter proximal pausing and its regulation by c-Myc in embryonic stem cells: ChIP-Seq Refer to individual Series
ORGANISM(S): Mus musculus 
2010-04-14 | E-GEOD-20485 | biostudies-arrayexpress
TranscriptomicsHuman and marmoset trophoblast stem cells differ in signalling requirements and recapitulate divergent modes of trophoblast invasion
We derive experimental conditions for the derivation of marmoset trophoblast like cells. Marmoset naïve PSC form extraembryonic mesoderm in human TSC conditions, whilst TGFβ/NODAL, FGF/ERK and WNT signalling control marmoset peri- and postimplantation trophoblast identity.
ORGANISM(S): Callithrix jacchus 
2024-11-21 | E-MTAB-12463 | biostudies-arrayexpress
TranscriptomicsGene Expression-Based Classifiers Identify Staphylococcus aureus Infection in Mice and Humans
Staphylococcus aureus causes a spectrum of human infection. Diagnostic delays and uncertainty lead to treatment delays and inappropriate antibiotic use. A growing literature suggests the hostM-bM-^@M-^Ys inflammatory response to the pathogen represents a potential tool to improve upon current diagno...
ORGANISM(S): Mus musculus 
2013-01-11 | E-GEOD-33341 | biostudies-arrayexpress
UnknownValidation of the OAKS prognostic model for acute kidney injury after gastrointestinal surgery.
Not available
S-EPMC8855527 | biostudies-literature
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