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GenomicsTransposon sequencing of E. coli in planktonic culture and in biofilms to determine the essentiality of genes throughout the biofilm life cycle
Biofilms undergo a life cycle where cells attach to a surface, grow and produce a structured community before dispersing to seed biofilms in new environments. Progression through this life cycle requires controlled temporal gene expression to maximise fitness at each stage. Previous studies have foc...
ORGANISM(S): Escherichia coli K-12 
2021-06-09 | E-MTAB-9873 | biostudies-arrayexpress
TranscriptomicsComparison of the genetic basis of biofilm formation between Salmonella Typhimurium and Escherichia coli
Most bacteria can form biofilms, which typically have a life cycle from cells initially attaching to a surface before aggregation and growth produces biomass and an extracellular matrix before finally cells disperse. To maximise fitness at each stage of this life cycle, and given the different event...
ORGANISM(S): Salmonella enterica subsp. enterica serovar Typhimurium 
2022-05-27 | E-MTAB-11765 | biostudies-arrayexpress
TranscriptomicsIdentification of RNA-RNA interactions in Bacillus Subtilis by in vivo UV crosslinking
Small RNAs (sRNAs) are a taxonomically-restricted but transcriptomically-abundant class of post-transcriptional regulators. While potentially of importance, we know the function of few. This is in no small part because we lack global-scale methodology enabling target identification, this being espec...
ORGANISM(S): Bacillus subtilis subsp. subtilis 
2021-08-25 | E-MTAB-8490 | biostudies-arrayexpress
UnknownAKT Inhibition in Solid Tumors With AKT1 Mutations.
Not available
S-EPMC5501365 | biostudies-literature
TranscriptomicsAnopheles gambiae immune responses to human and rodent Plasmodium parasite species
Transmission of malaria is dependent on the successful completion of the Plasmodium lifecycle in the Anopheles vector. Major obstacles are encountered in the midgut tissue, where most parasites are killed by the mosquito’s immune system. In the present study, DNA microarray analyses have been used t...
ORGANISM(S): Anopheles gambiae 
2007-08-15 | E-GEOD-8789 | biostudies-arrayexpress
TranscriptomicsSingle-cell transcriptomics of neonatal mouse anterior pituitary in steady-state conditions and after transgenically inflicted local damage
The mouse pituitary gland undergoes vivid maturation immediately after birth. During this process, the local stem cell compartment shows signs of activation including elevated abundance and expression of stemness pathways when compared to adult pituitary stem cells. In addition, we found that the ne...
ORGANISM(S): Mus musculus 
2022-07-11 | E-MTAB-11337 | biostudies-arrayexpress
TranscriptomicsSingle-cell transcriptomics of elderly mouse anterior pituitary in steady-state conditions and after transgenically inflicted local damage
The mouse pituitary gland houses a stem cell compartment which is known to suffer from an inflammatory phenotype at middle age (12-15 months), a process commonly referred to as ‘inflammaging’. Here, we investigate the aging pituitary stem cell phenotype by using single-cell RNA-sequencing interrogat...
ORGANISM(S): Mus musculus 
2025-01-06 | E-MTAB-14067 | biostudies-arrayexpress
TranscriptomicsAcquisition of alveolar fate and differentiation competence by human fetal lung epithelial progenitor cells
Our data show that Wnt and FGF signalling, and the downstream transcription factors NKX2.1 and TFAP2C, promote human alveolar or airway fate respectively. Moreover, we have functionally validated cell-cell interactions in human lung alveolar patterning. We show that Wnt signalling from differentiati...
ORGANISM(S): Homo sapiens 
2022-02-28 | E-MTAB-11435 | biostudies-arrayexpress
UnknownEstimating overdiagnosis in giant cell arteritis diagnostic pathways using genetic data: genetic association study.
Not available
S-EPMC11292050 | biostudies-literature
TranscriptomicsSEPN1-related myopathy depends on the ER oxidase ERO1 alpha and is responsive to the chemical chaperone TUDCA
SEPN1 is a type II protein of the endoplasmic reticulum (ER) whose loss of function gives rise to a collection of debilitating autosomal recessive myopathies gathered under the umbrella term of SEPN1-related myopathy (RM). At the moment, SEPN1-RM lacks an effective pharmacological treatment; thus, t...
ORGANISM(S): Mus musculus 
2024-02-14 | E-MTAB-12460 | biostudies-arrayexpress
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