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TranscriptomicsRemodeling of cell-type specific transcriptomes upon T cell stimulation in Systemic lupus erythematosus versus Sjögren’s syndrome
The RNA-sequencing to profile patient peripheral blood mononuclear cell (PBMC) samples of systemic lupus erythematosus (SLE, N=25), primary Sjögren’s syndrome (pSS, N=23), and healthy control (HD, N=24). We collected on the steady-state and 18-hours anti-CD3 culture to identify the transcriptome rem...
ORGANISM(S): Homo sapiens 
2023-12-20 | E-MTAB-12203 | biostudies-arrayexpress
TranscriptomicsSimultaneously inferring T cell fate and clonality from single cell transcriptomes
Single-cell RNA-seq from CD4+ T lymphocytes from uninfected steady-state mouse, two mice with Salmonella typhimurium infection at day 14 and one mouse at day 49 post-infection. Used to demonstrate application of reconstruction and analysis of T cell receptor sequences from single-cell RNA-seq.
ORGANISM(S): Mus musculus 
2016-03-06 | E-MTAB-3857 | biostudies-arrayexpress
TranscriptomicsIL-2 regulated genes in scurfy CD4+ T-cells
The goal of the study was to identify the genes which are regulated by Interleukin-2 in the CD4+ T cells of the scurfy mice during regulatory T-cell deficiency. Scurfy (Sf) mice bear a mutation in the forkhead box P3 (Foxp3) transcription factor, lack regulatory T-cells (Treg), develop multi-organ i...
ORGANISM(S): Mus musculus 
2012-09-18 | E-GEOD-23398 | biostudies-arrayexpress
TranscriptomicsExpression data from WT and IL-2 secondary CD4 T cell effectors responding towards infuenza A virus infection
How IL-2 produced by secondary CD4 T cell effectors, derived from resting memory cells, impacts memory CD4 T cell function and survival to memory following antigen re-encounter is unknown. We used microarrays to detail the global programme of gene expression underlying differences between WT and IL-...
ORGANISM(S): Mus musculus 
2015-05-14 | E-GEOD-60186 | biostudies-arrayexpress
TranscriptomicsGene expression profile of murine tolerant, self-antigen specific CD8 T cells
Genomewide microarray analysis of murine tolerant, self-antigen specific CD8 T cells to identify genes and pathways underlying peripheral T cell tolerance Gene signature of tolerant CD8 T cells was compared to the signatures of naïve T cells, memory T cells, rescued T cells (=tolerant T cells underg...
ORGANISM(S): Mus musculus 
2012-02-16 | E-GEOD-32025 | biostudies-arrayexpress
TranscriptomicsIdentification of the Early VIP Transriptome and its Associated Interactome in Activated Murine CD4 T Cells
Identification of the Early Vasoactive Intestinal Peptide (VIP) Transriptome and its Associated Interactome in Activated Murine CD4 T Cells In an attempt to understand the biological role of this neuropeptide in the immune system, we choose CD4 T cells as a cellular system for identifying a VIP-in...
ORGANISM(S): Mus musculus 
2010-01-09 | E-GEOD-18525 | biostudies-arrayexpress
TranscriptomicsIdentification of the Early VIP Transriptome and its Associated Interactome in Resting Murine CD4 T Cells
Identification of the Early Vasoactive Intestinal Peptide (VIP) Transriptome and its Associated Interactome in Resting Murine CD4 T Cells In an attempt to understand the biological role of this neuropeptide in the immune system, we choose CD4 T cells as a cellular system for identifying a VIP-indu...
ORGANISM(S): Mus musculus 
2010-01-09 | E-GEOD-18524 | biostudies-arrayexpress
TranscriptomicsGene expression signatures of 64 T-ALL patient diagnosis samples
Genetic studies have shown that human T-ALLs can be divided into subgroups that are characterized by unique gene expression signatures and relate to stages of T-cell differentiation at which the leukemic cells arrest. Each molecular subgroup has characteristic genetic abnormalities that cause aberra...
ORGANISM(S): Homo sapiens 
2014-10-14 | E-GEOD-62156 | biostudies-arrayexpress
TranscriptomicsIdentification of the Early VIP Transriptome and its Associated Interactome in Resting and Activated Murine CD4 T Cells
This SuperSeries is composed of the following subset Series: GSE18524: Identification of the Early VIP Transriptome and its Associated Interactome in Resting Murine CD4 T Cells GSE18525: Identification of the Early VIP Transriptome and its Associated Interactome in Activated Murine CD4 T Cells Refer...
ORGANISM(S): Mus musculus 
2010-01-09 | E-GEOD-18526 | biostudies-arrayexpress
GenomicsEarly T-helper 1 Differentiation Is Marked by A Follicular Helper-like Transition: Differential Roles of STAT4 and T-bet
Follicular helper T (Tfh) cells comprise an important subset of helper T cells; however, their relationship with other helper lineages is incompletely understood. Herein, we show IL-12 acting via signal transducer and activator of transcription 4 (STAT4) induced both Il21 and Bcl6 genes, generating ...
ORGANISM(S): Mus musculus 
2011-12-27 | E-GEOD-33802 | biostudies-arrayexpress
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