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TranscriptomicsRicochet transcription of pachytene piRNA promoters in mammals
The origin and stability of germline noncoding RNAs remain largely uncharacterized in mammals. Here, we demonstrate that the vast majority of pachytene piRNAs originate from less than 100 bi- and unidirectionally transcribed loci in the mouse genome. These loci show features characteristic of trans...
ORGANISM(S): Mus musculus 
2015-09-01 | E-MTAB-1265 | biostudies-arrayexpress
TranscriptomicsProfiling of Mili and Miwi2 associated piRNAs in WT, MiliDAH, Miwi2DAH and Miwi2KO from E16.5 gonadocytes.
Piwi proteins and piRNAs have conserved functions in transposonM- silencing. The murine Piwi proteins Mili and Miwi2 direct epigeneticM- LINE1 (L1) and intracisternal A particle (IAP) transposon silencingM- during genome reprogramming in the embryonic male germline. PiwiM- proteins are proposed to b...
ORGANISM(S): Mus musculus 
2011-10-28 | E-MTAB-730 | biostudies-arrayexpress
TranscriptomicsRNA-seq and ChIP-seq identification of unique and overlapping targets of GLI transcription factors in melanoma cell lines
Despite significant progress in therapy, melanoma is still the most lethal form of skin cancer, with a rising incidence worldwide. Little is known about the impact of deregulated Hedgehog-GLI (HH-GLI) signalling pathway in the progression of this disease. Based on previous research, we hypothesized ...
ORGANISM(S): Homo sapiens 
2023-01-01 | E-MTAB-11936 | biostudies-arrayexpress
TranscriptomicsDNA barcoding reveals ongoing immunoediting of clonal cancer populations during metastatic progression and in response to immunotherapy
Cancers evade the immune system in order to grow or metastasise through the process of cancer immunoediting. While checkpoint inhibitor therapy has been effective for reactivating tumour immunity in some cancers, many solid cancers, including breast cancer, remain largely non-responsive. Understandi...
ORGANISM(S): Mus musculus 
2021-09-01 | E-MTAB-10027 | biostudies-arrayexpress
TranscriptomicsThe retroelement Lx9 puts a brake on the immune response to virus infection
The mammalian genome has an abundance of transposable elements, but understanding their contribution to complex biological systems is poorly understood. Here, we report the CRISPR/Cas9 deletion of a retrotransposon (Lx9c11) in mice and its effect on the immune response to virus infection. The regula...
ORGANISM(S): Mus musculus 
2022-04-27 | E-MTAB-8436 | biostudies-arrayexpress
GenomicsThe ETS transcription factor ELF5 modulates estrogen action in breast cancer via participation in FOXA1-ER driven transcription.
The ETS transcription factor ELF5 drives mammary alveolar development in preparation for lactation by forcing differentiation within the progenitor cell population. In luminal A breast cancer, early disease progression is predicted by high levels of ELF5, and in preclinical models elevated ELF5 is a...
ORGANISM(S): Homo sapiens 
2020-01-06 | E-MTAB-7641 | biostudies-arrayexpress
TranscriptomicsIntergenic Disease-associated Regions are Abundant in Novel Regulatory Transcripts
Analysis of transcriptomes from 21 tissues, 13 melanoma samples and 7 breast cancer cell lines, enriched for transcripts from haploblocks with intronic and intergenic GWAS SNPs using CaptureSeq.
ORGANISM(S): Homo sapiens 
2017-07-04 | E-MTAB-4519 | biostudies-arrayexpress
GenomicsEGAS00001000212-sc-20120201 - samples
MuTHER adipose tissue small RNA expression
EGAD00001000105 | EGA
GenomicsMuTHER adipose tissue small RNA expression
We investigate the naturally occurring variation of small RNA expression in conjunction with genetic and gene expression variation. We shall assess the variation in subabdominal fat tissue small RNA levels in 168 unrelated MuTHER individuals. Using gene expression data from the same samples, we can ...
EGAS00001000212 | EGA
UnknownStromal cell diversity associated with immune evasion in human triple-negative breast cancer
Not available
S-SCDT-EMBOJ-2019-104063 | biostudies-other
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