Sort   by:  
 Page size 
ProteomicsCharacterization of intact proteomic profile of senescent-associated secretory phenotype (SASP) by top-down mass spectrometry.
Senescent cells are increasingly recognized as major contributors to age-related diseases, primarily through the secretion of bioactive molecules known as the senescence-associated secretory phenotype (SASP). The SASP plays a crucial role in promoting various age-related conditions, including neurod...
ORGANISM(S): Homo sapiens (Human) 
2025-12-29 | PXD061829 | Pride
Senescence  aging  top-down proteomics  proteoforms  biomarkers  sasp  senescence-associated secretory phenotype 
ProteomicsDeep and Quantitative Proteomic Profiling of Low Volume Mouse Serum Across the Lifespan
We developed a nanoparticle-based LC-MS workflow optimized for low-volume mouse serum samples, enabling deep, quantitative, and reproducible proteome profiling. Applied to aging cohorts, the approach identified 3,992 protein groups across all samples and uncovered age-associated proteomic signatures...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2025-07-02 | MSV000098399 | MassIVE
ProteomicsStable nuclear expression of ATP8 and ATP6 genes rescues a mtDNA Complex V null mutant
We explore the possibility of re-engineering mitochondrial genes and expressing them from the nucleus as an approach to rescue defects arising from mitochondrial DNA mutations. We have used a patient cybrid cell line with a single point mutation in the overlap region of the ATP8 and ATP6 genes of th...
ORGANISM(S): Homo Sapiens (human) 
2016-08-12 | MSV000080037 | MassIVE
ProteomicsIdentification of the Senescence Associated Secretory Phenotype from THP-1 Monocytes
Senescence was induced in THP-1 monocytes in culture and the senescence associated secretory phenotype (SASP) was measured for the complete conditioned medium by applying nanoparticle based Proteograph technology for enrichment followed by DIA mass spectrometry
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-07-12 | MSV000095315 | MassIVE
ProteomicsProteomic Profiling of Human Plaque Compartments: Fibrous Cap, Core, and Media
The proteome of human plaque, fibrous cap, core, and media was unveiled using fully automated sample preparation platform AccelerOme and cutting-edge DIA mass spectrometry.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2025-02-24 | MSV000097207 | MassIVE
ProteomicsLate-life restoration of mitochondrial function reverses cardiac dysfunction in old mice
Redox proteomic data from the heart of young mice, old mice, or mice treated with SS31. Quantification of protein-S-glutathionylation was performed using an established redox proteomics workflow. LC-MS/MS raw data were searched with MS-GF+ against the mouse protein sequence database from the Uniprot...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2020-04-23 | MSV000085329 | MassIVE
Sort   by:  
 Page size