Sort   by:  
 Page size 
TranscriptomicsGenome-wide CRISPR-Cas9 screens reveal loss of redundancy between PKMYT1 and WEE1 in Glioblastoma stem-like cells
To identify new therapeutic targets for Glioblastoma (GBM), we performed genome-wide CRISPR-Cas9 "knockout" (KO) screens in patient-derived GBM stem-like cells (GSCs) and human neural stem/progenitors (NSCs), non-neoplastic stem cell controls, for genes required for their in vitro growth. ...
ORGANISM(S): Homo sapiens 
2016-02-15 | E-GEOD-70038 | biostudies-arrayexpress
TranscriptomicsDamID-based chromatin profiling of UpSET in Kc cells and chromatic accesibility evaluation in UpSET knock down Kc cells
Developmental gene expression results from the orchestrated interplay between genetic and epigenetic mechanisms. Here, we describe upSET, a transcriptional regulator encoding a SET domaincontaining protein recruited to active and inducible genes in Drosophila. However, unlike other Drosophila SET pr...
ORGANISM(S): Drosophila melanogaster 
2012-12-07 | E-GEOD-34718 | biostudies-arrayexpress
TranscriptomicsUpSET Recruits HDAC Complexes and Restricts Chromatin Accessibility and Acetylation at Promoter Regions
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Drosophila melanogaster 
2012-12-07 | E-GEOD-34720 | biostudies-arrayexpress
TranscriptomicsCells Comprising the Prostate Cancer Microenvironment Lack Recurrent Clonal Somatic Genomic Aberrations
Prostate cancer-associated stroma (CAS) plays an active role in malignant transformation, tumor progression, and metastasis. Molecular analyses of CAS have demonstrated significant changes in gene expression; however, conflicting evidence exists on whether genomic alterations in benign cells compris...
ORGANISM(S): Homo sapiens 
2016-02-12 | E-GEOD-76456 | biostudies-arrayexpress
TranscriptomicsWhole genome transcriptome analysis of tumor-specific CD8 T cells in pre-malignant lesions
Gene expression analysis of tumor-specific CD8 T cells encountering a tumor-specific antigen in pre-malignant lesions in the liver at different time points post tumor initiation. The overall goal of this mouse study was to elucidate the molecular program in tumor-specific T cells encountering a tumo...
ORGANISM(S): Mus musculus 
2016-08-11 | E-GEOD-60501 | biostudies-arrayexpress
TranscriptomicsGene expression profile of murine Flvcr-deleted and control CD4+CD8+ double-positive (DP) thymocytes
Genomewide microaarray analysis of murine DP thymocytes to determine the genes whose expression was altered by FLVCR loss Gene signatures from Flvcr+/+ DP thymocytes was compared to gene signatures from Flvcr-/- DP thymocytes Total RNA obtained from sort-purified Flvcr-/- and Flvcr+/+ DP thymocytes
ORGANISM(S): Mus musculus 
2015-02-17 | E-GEOD-50202 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of human CD8+ CD161hi and CD161lo memory and naïve T cell subsets
Gene expression profiling of human CD8+ CD161hi and CD161lo central and effector memory and naïve T cell subsets. The mechanisms by which IL-17 secreting cells are regulated have not been completely elucidated. We previously identified a population of rhodamine-effluxing memory CD8+ T cells with hi...
ORGANISM(S): Homo sapiens 
2011-07-31 | E-GEOD-23663 | biostudies-arrayexpress
Sort   by:  
 Page size