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ProteomicsDeep proteomic analysis of small arteries unravels critical changes associated with early-onset high blood pressure in hypertensive rats
Background: The vascular wall of small arteries is heavily affected by high blood pressure. However, the underlying mechanisms causing vascular changes are not fully elucidated. Using a novel data-independent acquisition mass spectrometry (DIA-MS) approach, we aimed to determine the proteomic change...
ORGANISM(S): Rattus norvegicus (Rat) 
2022-01-06 | PXD026051 | Pride
Mesenteric arteries Rat Hypertension Blood pressure Dia 
ProteomicsDeclining activity of serum response factor in aging arteries in relation to aortic aneurysm initiation and progression
public RNA-sequencing data were leveraged to define how the transcriptome of healthy human arteries remodels with age, uncovering both known and novel age-dependent processes. We demonstrate for the first time that the SRF regulon is gradually depleted in the aging arterial wall, and that this, when...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-07 | PXD055964 | Pride
Myosin light chain kinase Leiomodin Myocardin Smooth muscle gamma-actin Hypertension Angiotensin 
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