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ProteomicsProteoMixture: A Cell Deconvolution Tool for Bulk Tissue Proteomics Data
Numerous multi-omic investigations of cancer tissue have documented varying and poor pairwise transcript:protein quantitative correlations and most deconvolution tools aiming to predict cell type proportions (cell admixture) have been developed and credentialed using transcript-level data alone. To ...
ORGANISM(S): Homo sapiens (Human) 
2024-01-12 | PXD044157 | Pride
Laser microdissection High grade serous ovarian cancer Proteomics Stroma signature Immune signature Cellular admixture Tumor signature 
ProteomicsProteogenomic analysis of lung adenocarcinoma reveals tumor heterogeneity, survival determinants and therapeutically-relevant pathways
To characterize the etiology of lung adenocarcinoma (LUAD) in the United States, we performed deep proteogenomic profiling of 87 tumors integrating whole genome sequencing, transcriptome sequencing, proteomics and phosphoproteomics by mass spectrometry and reverse phase protein arrays. Somatic genom...
ORGANISM(S): Homo sapiens (Human) 
2022-11-16 | PXD036025 | Pride
Apollo Lung adenocarcinoma 
ProteomicsExtensive Three-Dimensional Intratumor Proteomic Heterogeneity Revealed by Multiregion Sampling in High-Grade Serous Ovarian Tumor Specimens
Enriched tumor epithelium, tumor-associated stroma, and whole tissue were collected by laser microdissection from thin sections across spatially separated levels of ten high-grade serous ovarian carcinomas (HGSOC) and analyzed by mass spectrometry. Unsupervised analyses of protein abundance data rev...
ORGANISM(S): Homo sapiens (Human) 
2021-07-01 | PXD026570 | Pride
Laser microdissection Proteomics Heterogeneity High grade serous ovarian cancer Tumor microenvironment 
ProteomicsAlzheimer's Disease Isomerization
Amino acid isomerization is a spontaneous chemical modification potentially related to the underlying causes of Alzheimer’s disease (AD). We demonstrate that data-independent acquisition mass spectrometry can be used to characterize isomerization in complex protein mixtures. Examination of a large c...
ORGANISM(S): Homo Sapiens 
2022-03-16 | PXD025668 | panorama
ProteomicsA Peptide-Centric Quantitative Proteomics Dataset for the Phenotypic Assessment of Alzheimer’s Disease
Alzheimer’s disease (AD) is a looming public health disaster with limited interventions. Desperately needed progress in therapeutic development rests on more detailed understanding of molecular pathogenesis. The vast majority of existing data for AD pathogenesis in humans is from standard neuropatho...
ORGANISM(S): Homo Sapiens 
PXD034525 | panorama
UnknownDevelopment of a Definition of Postacute Sequelae of SARS-CoV-2 Infection.
Not available
S-EPMC10214179 | biostudies-literature
UnknownAmyloid and Tau Pathology Associations With Personality Traits, Neuropsychiatric Symptoms, and Cognitive Lifestyle in the Preclinical Phases of Sporadic and Autosomal Dominant Alzheimer's Disease.
Not available
S-EPMC7415608 | biostudies-literature
UnknownIntermittent versus continuous oxaliplatin and fluoropyrimidine combination chemotherapy for first-line treatment of advanced colorectal cancer: results of the randomised phase 3 MRC COIN trial.
Not available
S-EPMC3159416 | biostudies-literature
UnknownAddition of cetuximab to oxaliplatin-based first-line combination chemotherapy for treatment of advanced colorectal cancer: results of the randomised phase 3 MRC COIN trial.
Not available
S-EPMC3159415 | biostudies-literature
UnknownAccelerated functional brain aging in pre-clinical familial Alzheimer's disease.
Not available
S-EPMC8429427 | biostudies-literature
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