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ProteomicsPhenotypic profiling of human induced regulatory T cells at early differentiation: insights into distinct immunosuppressive potential
Regulatory T cells (Tregs) play a key role in suppressing systemic effector immune responses, thereby preventing autoimmune diseases but could also potentially contribute to tumor progression. As a result, there is significant interest in the clinical manipulation of Tregs. However, the mechanisms g...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD052626 | Pride
Faims Dia Foxp3 Treg T cell differentiation Cd103 
ProteomicsProteomics reveals the essential role for LPXN in human iTreg suppression
Regulatory T cells are critical in the modulation of immune responses. Accordingly, the manipulation and implementation of in vitro induced Treg cells to control immune function has a significant potential in clinical medicine. However, the use of iTregs as therapeutics is complicated by their poor ...
ORGANISM(S): Homo Sapiens 
PXD052690 | panorama
ProteomicsHIC1 interacts with FOXP3 multi protein complex: a novel mechanism to regulate human regulatory T cell differentiation and function
Transcriptional repressor, hypermethylated in cancer 1 (HIC1) is an important contributor to regulatory T (Treg) cell development and function. To investigate the mechanism by which it regulates Treg cell development, we systematically characterized the HIC1 interactome by affinity-purification mass...
ORGANISM(S): Homo Sapiens 
PXD038532 | panorama
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