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To discover novel growth factors for hematopoietic stem- and progenitor cells (HSPCs), we have assessed cytokine responses of cord blood (CB)-derived CD34+ cells in a high-content growth factor screen. We identify the immunoregulatory chemokine (C-C motif) ligand 28 (CCL28) as a novel growth factor ...
ORGANISM(S): Homo sapiens 
Oil-bodies are sites of energy storage in many organisms including microalgae. As a first step toward understanding oil accumulation in algae, we took a proteomic approach on purified oil-body fraction from the model microalga Chlamydomonas reinhardtii grown under nitrogen deprivation. Among the 240...
ORGANISM(S): Chlamydomonas reinhardtii 
2012-01-05 | PRD000394 | Pride
During axon pathfinding, growth cones commonly exhibit changes in sensitivity to guidance cues that follow a strict timetable, even in the absence of pathway feedback, implicating cell-intrinsic regulation. Cellular timer mechanisms, however, are poorly understood. Here we have investigated microRNA...
ORGANISM(S): Xenopus laevis 
We identified chemokine (C-C motif) ligand 28 (CCL28) as a novel growth factor for HSPCs with the ability to enhance the proliferation potential of fetal, neonatal and adult CD34+ HSPCs after one week of culture in serum-free medium containing limiting stem cell factor (SCF) concentrations. Importan...
ORGANISM(S): Homo sapiens 
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