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TranscriptomicsGene therapy of Mpl -/- mouse LSK cells
Comparison of Mpl-/- mouse LSK cells, either treated with control (GFP) or Mpl lentivirus. Lineage negative bone marrow cells were isolated and transduced and transplanted into Mpl-/- recipient mice. After transplantation and follow up mice were sacrificed and LSK (lineage negative, Sca-1 positive, ...
ORGANISM(S): Mus musculus 
2011-01-03 | E-GEOD-26403 | biostudies-arrayexpress
TranscriptomicsExpression in LT-HSC after in vitro culture in mSCF, mTpo, mFlt3L, hIGFBP2 and Angptl5.
Mouse LT-HSC were sorted and cultured in mScf, mTpo, mFlt3L, hIGFBP2 and Angptl5 for 2 days. These expression values were related to insertions of gamma-retroviral, lentiviral or alpharetroviral vectors carrying GFP which were retrieved after serial murine BM transplantation. The relation between ge...
ORGANISM(S): Mus musculus 
2011-12-28 | E-GEOD-34731 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse embryoid bodies with HOXB4 induced or not induced to identify its target genes
To unravel the molecular mechanism by which HOXB4 promotes the expansion of early hematopoietic progenitors within differentiating ES cells, we analzed the gene expression profiles of embryoid bodies (EBs) in which transcription of HOXB4 had been induced or not induced. A substantial number of the i...
ORGANISM(S): Mus musculus 
2008-06-16 | E-GEOD-9044 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse HOXB4 in adult hematopoietic stem and progenitor cells with inducible HOXB4 to identify its target genes
HOXB4 mediates expansion of adult and embryo-derived hematopoietic stem cells (HSCs) when expressed ectopically. To define the underlying molecular mechanisms, we performed gene expression profiling in combination with subsequent functional analysis using enriched adult HSCs expressing inducible HO...
ORGANISM(S): Mus musculus 
2008-06-16 | E-GEOD-9010 | biostudies-arrayexpress
UnknownEfficacy and Safety of Degludec versus Glargine in Type 2 Diabetes.
Not available
S-EPMC5731244 | biostudies-literature
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