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GenomicsBrain endothelial GSDMD activation mediates inflammatory BBB breakdown
Brain endothelial GSDMD activation mediates inflammatory BBB breakdown
PRJNA868813 | ENA
TranscriptomicsAlbumin, TGF-Beta1 and Blood-Brain Barrier opening induce cortical epileptogenesis.
Insults to the cerebral cortex, such as trauma, ischemia or infections, may result in the development of epilepsy, one of the most common neurological disorders. Previous studies have suggested that perturbations in neurovascular integrity and breakdown of the blood-brain barrier (BBB) lead to neuro...
ORGANISM(S): Rattus norvegicus 
2009-07-15 | E-GEOD-12304 | biostudies-arrayexpress
GenomicsAngiopoietin-2 aggravates Alzheimer’s disease by promoting BBB breakdown and neuroinflammation.
Angiopoietin-2 aggravates Alzheimer’s disease by promoting BBB breakdown and neuroinflammation.
PRJNA1208978 | ENA
TranscriptomicsBrain endothelial GSDMD activation mediates inflammatory BBB breakdown
The blood-brain barrier (BBB) protects the central nervous system (CNS) from external assaults by pathogenic or harmful substances. BBB impairment frequently occurs during infection, inflammatory, or other pathological conditions, which causes or exacerbates a wide range of CNS diseases. Using singl...
ORGANISM(S): Mus musculus 
2024-02-22 | GSE211099 | GEO
GenomicsNanostring protein expression of immune cell recruitment and BBB breakdown following Aβ immunotherapy
Nanostring protein expression of immune cell recruitment and BBB breakdown following Aβ immunotherapy
PRJNA1065446 | ENA
TranscriptomicsMicroglia drive diurnal variation in susceptibility to inflammatory blood-brain barrier breakdown
The blood brain barrier (BBB) is critical for maintaining brain homeostasis but is susceptible to inflammatory breakdown. Permeability of the BBB to polar molecules shows circadian variation due to rhythmic transporter expression, while basal permeability to polar molecules in non-rhythmic. Whether ...
ORGANISM(S): Mus musculus 
2024-12-06 | GSE263794 | GEO
GenomicsMicroglia drive diurnal variation in susceptibility to inflammatory blood-brain barrier breakdown
Microglia drive diurnal variation in susceptibility to inflammatory blood-brain barrier breakdown
PRJNA1099251 | ENA
TranscriptomicsAngiopoietin-2 aggravates Alzheimer’s disease by promoting BBB breakdown and neuroinflammation.
Disruption of the blood-brain barrier (BBB) and increased vascular leakage contribute to neuroinflammation in Alzheimer’s disease (AD), driving disease pathogenesis and progression. However, the mechanisms underlying BBB dysfunction and neuroinflammation in AD remain unclear. Angiopoietin-2 (ANGPT2)...
ORGANISM(S): Mus musculus 
2026-04-15 | GSE286360 | GEO
ProteomicsAPOE4 cell-specific mechanisms underlying cerebrovascular disorder precede neuronal and synaptic dysfunction and cognitive deficits in mice
Apolipoprotein E4 (APOE4), the main susceptibly gene for Alzheimer’s disease1–5, exerts cerebrovascular toxicity6 leading to blood-brain barrier (BBB) breakdown in humans7–9 and APOE4 transgenic mice10–13. Moreover, an early BBB dysfunction predicts cognitive decline in humans7. However, the compre...
ORGANISM(S): Mus musculus (Mouse) 
2022-08-23 | PXD029230 | Pride
Phosphoproteome Alzheimer’s disease Signaling networks Single cell rna-seq Apoe4 Bbb breakdown Interactome Blood-brain barrier 
ProteomicsBrain microvascular endothelial cells: INSR KD
The insulin receptor (INSR) mediates insulin signaling to modulate cellular functions. Although INSR is expressed at the blood-brain barrier (BBB), its role in the modulation of BBB function is poorly understood. Therefore, in this study, we aimed to analyze the effect of INSR knockdown on the expre...
ORGANISM(S): Homo Sapiens (human) 
2021-12-25 | PXD027326 | JPOST Repository
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