Albumin, TGF-Beta1 and Blood-Brain Barrier opening induce cortical epileptogenesis.

ABSTRACT: Insults to the cerebral cortex, such as trauma, ischemia or infections, may result in the development of epilepsy, one of the most common neurological disorders. Previous studies have suggested that perturbations in neurovascular integrity and breakdown of the blood-brain barrier (BBB) lead to neuronal hypersynchronization and epileptiform activity, but the underlying mechanisms are unknown. As with BBB opening, treatment with albumin or with TGF-?1 results in the development of hypersynchronized epileptiform activity. Given the latent period before the appearance of epileptiform activity, we hypothesized the underlying mechanism is a transcriptional response which would be similar for BBB breakdown and exposure to albumin or TGF-?1. In search of a common pathway and transcriptional activa

ORGANISM(S): Rattus norvegicus

SUBMITTER: Luisa Cacheaux 

PROVIDER: E-GEOD-12304 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress