Bcl-2 family - OmicsDI

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Department of Biochemistry & Molecular Biology, Monash Biomedicine Discovery Institute, Monash University, Clayton 3800, Australia (1)
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Prof. Dr. Oliver Schilling Heisenberg Professor of Translational Proteomics Institute of Surgical Pathology Faculty of Medicine University of Freiburg Breisacher Strasse 115a D-79106 Freiburg, Germany +49 761 27080610 oliver.schilling@mol-med.uni-freiburg.de (1)
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Bavarian Center for Biomolecular Mass Spectrometry at Klinikum rechts der Isar (BayBioMS@MRI), TUM School of Medicine and Health, Technical University of Munich (TUM), 81675 München, Germany (1)

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Transcription profiling of human SCLC cell line set 2

RNA expression analysis was performed to compare patterns to sensitivity to BCL2 inhibitors (ABT-263). Overexpression of the prosurvival Bcl-2 family members (Bcl-2, Bcl-xL and Mcl-1) is commonly associated with tumor maintenance, progression and chemoresistance. We previously reported the discover...

ORGANISM(S): Homo sapiens

2008-06-19 | E-GEOD-10841 | biostudies-arrayexpress

Comprehensive profiling and targeting of BCL-2 family members in nasopharyngeal carcinoma

PRJNA986493 | ENA

Progress in targeting the BCL-2 family of proteins.

Not available

S-EPMC5667545 | biostudies-literature

BCL-2 Regulation and Upstream Signal Transduction Modulate Venetoclax Resistance in Multiple Myeloma: New Avenues for Therapeutic Intervention

This study aimed to investigate the mechanisms underlying venetoclax (VTX) resistance in multiple myeloma (MM) and develop strategies to prevent or overcome resistance. VTX resistant human myeloma cell lines (HMCLs) were established and analyzed using whole exome sequencing (WES), mRNA-sequencing (m...

ORGANISM(S): Homo sapiens (Human)

2025-05-06 | PXD047149 | Pride

The BCL-2 family reunion.

Not available

S-EPMC3222298 | biostudies-literature

Transcription profiling of human lymphocyte response to E. coli to identify any transcriptional component to the protection in vitro bacterially induced PBMC apoptosis

Sepsis induces lymphocyte apoptosis which can be prevented by over-expression of anti-apoptotic Bcl-2 family members. The anti-apoptotic activity of Bcl-2 family members is localized in the BH4 domain. The therapeutic peptide, TAT-BH4, was found to prevent sepsis-induced lymphocyte apoptosis in vi...

ORGANISM(S): Homo sapiens

2006-02-07 | E-MEXP-555 | biostudies-arrayexpress

Bcl-2 family member Bcl-G is not a proapoptotic protein.

Not available

S-EPMC3481120 | biostudies-literature

BCL-2 levels do not predict azathioprine treatment response in inflammatory bowel disease, but inhibition induces lymphocyte apoptosis and ameliorates colitis in mice.

Background: Inducing apoptosis of autoreactive lymphocytes is part of the therapeutic strategy for Crohn’s disease (CD) patients. Failure to respond to medical therapies upon inflammatory bowel disease could result from insufficient apoptosis. To date there are no useful molecular factors for the pr...

ORGANISM(S): Homo sapiens

2018-05-14 | E-MTAB-6739 | biostudies-arrayexpress

Comprehensive profiling and targeting of BCL-2 family members in nasopharyngeal carcinoma

Nasopharyngeal carcinoma (NPC) is among a small number of solid tumors that are caused by the Epstein-Barr virus (EBV). Recently, BH3 mimetics, a novel class of drugs that inhibit pro-survival proteins of the BCL-2 family, have demonstrated clinical anti-cancer efficacy in hematological malignancies...

ORGANISM(S): Homo sapiens

2024-10-01 | GSE235574 | GEO

BCL-2 Family Inhibition Enhances mTORC1/2 Inhibition in PIK3CA-Mutant Colorectal Cancer.

Not available

S-EPMC12767208 | biostudies-literature

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