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ProteomicsDHODH is a synthetic-lethal vulnerability in BCOR-deficient acute myeloid leukemia
Acute Myeloid Leukemia (AML) remains challenging to treat, especially in cases with mutations in the BCL-6 co-repressor (BCOR), which are associated with poor prognosis and chemo-resistance. In this study, we reveal a synthetic lethal interaction between BCOR and dihydroorotate dehydrogenase (DHODH)...
ORGANISM(S): Homo sapiens (Human) 
2026-09-24 | PXD062779 | Pride
Acute myeloid leukemia Bcor Am Bcl-6 co-repressor 
UnknownInhibition of the transcriptional repressor complex Bcl-6/BCoR induces endothelial sprouting but does not promote tumor growth.
Not available
S-EPMC5352177 | biostudies-literature
UnknownIL-7 signalling represses Bcl-6 and the TFH gene program.
Not available
S-EPMC4729877 | biostudies-literature
TranscriptomicsBCOR-regulated genes in human oculo-facio-cardio-dental syndrome
Oculo-facio-cardio-dental syndrome (OFCD) is a rare genetic disorder characterized by teeth with extremely long roots (radiculomegaly), and craniofacial, eye and cardiac abnormalities. The mutation of the transcriptional co-repressor BCOR has been identified as being responsible for oculo-facio-card...
ORGANISM(S): Homo sapiens 
2009-07-23 | E-GEOD-15214 | biostudies-arrayexpress
UnknownBCOR regulates mesenchymal stem cell function by epigenetic mechanisms.
Not available
S-EPMC2752141 | biostudies-literature
TranscriptomicsMdm2 enhances stemness-promoting chromatin modifications through the Polycomb Repressor Complex 2 in a p53-Independent Manner [RNA-Seq]
The Mdm2 oncoprotein ubiquitinates and antagonizes p53 but may also carry out p53-independent functions. Here we report that Mdm2 is required for the efficient generation of induced pluripotent stem cells (iPSCs) from murine embryonic fibroblasts, in the absence of p53. Similarly, Mdm2 depletion in ...
ORGANISM(S): Mus musculus 
2015-12-31 | E-GEOD-73176 | biostudies-arrayexpress
UnknownA novel POK family transcription factor, ZBTB5, represses transcription of p21CIP1 gene.
Not available
S-EPMC2740411 | biostudies-literature
UnknownRecurrent internal tandem duplications of BCOR in clear cell sarcoma of the kidney.
Not available
S-EPMC4660214 | biostudies-literature
UnknownBCOR mutations define a therapeutic vulnerability to DHODH Inhibition in acute myeloid leukemia.
Not available
S-EPMC12812770 | biostudies-literature
UnknownThe proto-oncoprotein FBI-1 interacts with MBD3 to recruit the Mi-2/NuRD-HDAC complex and BCoR and to silence p21WAF/CDKN1A by DNA methylation.
Not available
S-EPMC3711425 | biostudies-literature
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