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TranscriptomicsLarge airway epithelial cells from cigarette smokers with and without lung cancer undergoing flexible bronchoscopy in the operating room for resection of a suspicious lung nodule
mRNA expression was assayed from bronchial epithelial cell samples from smokers with and without lung cancer. A subset of the samples (2 of the lung cancer samples and 3 of the no cancer samples) were pooled and underwent whole transcriptome sequencing. The goals were to compare whole transcriptom...
ORGANISM(S): Homo sapiens 
2011-06-01 | E-GEOD-28835 | biostudies-arrayexpress
TranscriptomicsmRNA-seq of Human Airway Epithelial Cells
mRNA expression was profiled from pooled bronchial airway epithelial cell brushings (n=3 patients/pool) obtained during bronchoscopy from healthy never (NS) and current smokers (S) and smokers with (C) and without (NC) lung cancer 4 samples were sequened, each representing a pool of 3 patients. The...
ORGANISM(S): Homo sapiens 
2011-06-01 | E-GEOD-29006 | biostudies-arrayexpress
TranscriptomicsCharacterization of the mid-foregut transcriptome identifies genes regulated during lung bud induction.
To identify genes expressed during initiation of lung organogenesis, we generated transcriptional profiles of the prospective lung region of the mouse foregut (mid-foregut) microdissected from embryos at three developmental stages between embryonic day 8.5 (E8.5) and E9.5. This period spans from lun...
ORGANISM(S): Mus musculus 
2010-01-14 | E-GEOD-19873 | biostudies-arrayexpress
ProteomicsMetabolic reprogramming in the airway epithelium of high risk individuals
We investigated proteins identified by shotgun proteomics in cytologically normal airway epithelial cells from individuals at different levels of risk for lung cancer. We identified 2869 proteins in bronchial brushings from individuals at low, moderate or high risk for lung cancer. Pathway analysis ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
MSV000079331 | MassIVE
ProteomicsComparative Tissue Proteomics for the Diagnosis of Indeterminate Pulmonary Nodules
We identified candidate protein biomarkers to distinguish lung adenocarcinomas from benign nodules. We employed shotgun proteomics using a multidimensional peptide separation approach coupled to tandem mass spectrometry (LC-MS/MS) to characterize proteomes of a collection of 34 benign lung nodules. ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-10-09 | MSV000080236 | MassIVE
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