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ProteomicsThe Legionella-driven PtdIns(4)P gradient at LCV-ER membrane contact sites promotes Vap-, OSBP and Sac1-dependent pathogen vacuole remodeling
The causative agent of Legionnaires’ disease, Legionella pneumophila, governs interactions with host cells by secreting ca. 330 different “effector” proteins. The facultative intracellular bacteria replicate in macrophages and amoeba within a unique compartment, the Legionella-containing vacuole (LC...
ORGANISM(S): Legionella pneumophila subsp. pneumophila str. Philadelphia 1 Dictyostelium discoideum 
2023-02-21 | PXD034490 | Pride
Large fusion gtpase Oxysterol binding protein Legionella pneumophila Atlastin Legionnaires’ disease Host-pathogen interaction Pathogen vacuole Amoeba Dictyostelium discoideum 
ProteomicsA conserved cysteine acts as an endogenous antioxidant in the P-type plasma membrane H+-ATPase
Sulfur-containing amino acid residues function in antioxidative responses, which can be induced by the reactive oxygen species generated by excessive copper and hydrogen peroxide. In all Na+/K+, Ca2+, and H+ pumping P-type ATPases, a cysteine residue is present two residues upstream of the essential...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2021-08-10 | PXD022964 | Pride
Conserved cysteine Endogenous antioxidant Proton pump 
ProteomicsThe Outer Membrane Vesicle-Associated Peptidyl-arginine Deiminase of Porphyromonas gingivalis is Required for Macrophage Evasion and Modulates Blood-Brain Barrier passage
Porphyromonas gingivalis is a keystone periodontal pathogen implicated in a variety of diseases ranging from periodontitis to Alzheimer’s disease. A hallmark of P. gingivalis is the constitutive production of a peptidyl-arginine deiminase (PPAD), which converts positively charged arginine residues i...
ORGANISM(S): Porphyromonas gingivalis (strain ATCC BAA-308 / W83) 
2026-05-14 | PXD066207 | Pride
Macrophages Blood-brain-barrier Ppad Omvs Porphyromonas gingivalis 
ProteomicsPeptide-based quorum sensing systems in Paenibacillus polymyxa
Paenibacillus polymyxa is an agriculturally important plant growth promoting rhizobacterium (PGPR). Many Paenibacillus species are known to be engaged in complex bacteria-bacteria and bacteria-host interactions, which in other bacteria were shown to necessitate quorum sensing communication, but to d...
ORGANISM(S): Paenibacillus polymyxa ATCC 842 
2020-08-05 | PXD015319 | Pride
Paenibacillus polymyxa Communication system Peptides Quorum sensing 
ProteomicsImpact of SliP4 deletion on the high-light acclimation in Synechocystis sp. PCC 6803
SliP4 is a 37 amino acids small protein that is strongly induced when the cyanobacterium Synechocystis is exposed to high-light conditions. Deletion mutants exhibit a light-sensitive phenotype due to impaired cyclic electron flow and state transitions. Here, we investigated the consequences of SliP4...
ORGANISM(S): Synechocystis sp. PCC 6803 
2026-02-09 | PXD065318 | Pride
Metabolome High light Photosynthesis Gene expression Proteome 
ProteomicsScaffold_pairwise, single and consortia
The bacterial strains P. ruminicola ATCC 19189, M. elsdenii DSM 20460, B. fibrisolvens DSM 3071, E. hallii DSM 3353, R. intestinalis DSM 14610, M. formatexigens DSM 14469 and F. prausnitzii DSM 17677 were cultivated as single cultures, in pairwise cultures and full consortia. Bacteria were grown ana...
ORGANISM(S): Anaerobutyricum hallii DSM 3353 Faecalibacterium prausnitzii Marvinbryantia formatexigens DSM 14469 Roseburia intestinalis L1-82 Butyrivibrio fibrisolvens DSM 3071 Megasphaera elsdenii DSM 20460 Xylanibacter ruminicola 
2026-02-19 | PXD072222 | Pride
Microbial productivity Proteomics Gut microbiome Synthetic communities 
UnknownCharacterization of helper virus-independent cytopathogenic classical swine fever virus generated by an in vivo RNA recombination system.
Not available
S-EPMC546568 | biostudies-literature
ProteomicsOral Pathogen ‘Neutralizes’ the Human Innate Immune Defence
Our present findings show for the first time that the virulence factor PPAD protects the oral pathogen P. gingivalis against neutrophil insults at three distinct levels, namely phagocytosis, NETosis and CAMP activity. This identifies PPAD as a major agent in the evasion of human innate immunity, a v...
ORGANISM(S): Homo sapiens (Human) 
2018-10-15 | PXD010798 | Pride
Human Neutrophils P. gingivalis Ppad Lc-ms/ms 
UnknownRNA recombination between persisting pestivirus and a vaccine strain: generation of cytopathogenic virus and induction of lethal disease.
Not available
S-EPMC114347 | biostudies-literature
UnknownPrecursor of H-type II histo-blood group antigen and subterminal sialic acids on gangliosides are significantly implicated in cell entry and infection by a porcine P[11] rotavirus.
Not available
S-EPMC11727068 | biostudies-literature
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