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GenomicsGenome-wide Analysis of Transcriptional Regulators in Human Blood Stem/Progenitor Cells reveals a densely interconnected network of coding and non-coding genes.
Combinatorial transcription factor (TF) interactions regulate hematopoietic stem cell formation, maintenance and differentiation, and are increasingly recognised as drivers of stem cell signatures in cancer. However, genome-wide combinatorial binding patterns for key regulators do not exist in prim...
ORGANISM(S): Homo sapiens 
2013-09-03 | E-GEOD-45144 | biostudies-arrayexpress
GenomicsWhole-genome GR binding sites and histone acetylation status in pediatric acute lymphoblastic leukemia patient-derived xenografts following dexamethasone treatment in vivo
Glucocorticoids are critical components of combination chemotherapy regimens in pediatric acute lymphoblastic leukemia (ALL). However, the signaling pathways regulating apoptosis in glucocorticoid-treated lymphoid cells remain unclear. In this study, pediatric ALL patient-derived xenograft inherentl...
ORGANISM(S): Homo sapiens 
2014-12-18 | E-GEOD-58266 | biostudies-arrayexpress
TranscriptomicsHigh ERG expression in human HSPCs promotes progenitor but not stem cell proliferation and molecular signatures that are enriched in high ERG leukemia.
ERG is an Ets-transcription factor required for normal blood stem cell development. High ERG expression in acute myeloid leukemia (AML) and acute T-cell lymphoblastic leukemia (T-ALL) is associated with a stem cell signature and poor prognosis. In murine over-expression models, human ERG is a pote...
ORGANISM(S): Homo sapiens 
2014-10-31 | E-GEOD-53665 | biostudies-arrayexpress
GenomicsSalt augments macrophage-driven host defense in the skin
Immune cells regulate a hypertonic microenvironment in the skin; however, possible functions of increased skin Na+ concentrations are unknown. We found that Na+ accumulated at the site of bacterial skin infections in humans and in mice. We used the protozoan parasite Leishmania (L.) major as a model...
ORGANISM(S): Mus musculus 
2015-02-26 | E-MTAB-3343 | biostudies-arrayexpress
UnknownBiallelic NUDT2 variants defective in mRNA decapping cause a neurodevelopmental disease.
Not available
S-EPMC10994549 | biostudies-literature
TranscriptomicsExpression data of leukemia samples taken from transgenic ERG mice
The Ets transcription factor, ERG, plays a central role in definitive hematopoiesis and its overexpression in acute myeloid leukemia is associated with a stem cell signature and bad prognosis. However, little is known about the underlying mechanism by which ERG causes leukemia. Therefore we sought t...
ORGANISM(S): Mus musculus 
2013-08-13 | E-GEOD-49787 | biostudies-arrayexpress
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