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TranscriptomicsThe MOF-containing NSL complex associates globally with housekeeping genes, but activates only a defined subset (RNAi)
The MOF-containing NSL complex binds to many but not all promoters of active genes and potentially contributes to their proper gene expression. It is currently unknown what determines whether an active gene is bound or not. Here, we provide evidence that the NSL complex primarily targets active prom...
ORGANISM(S): Drosophila melanogaster 
2011-10-28 | E-GEOD-30990 | biostudies-arrayexpress
ProteomicsProteomic identification of an endogenous synaptic SUMOylome in the developing rat brain
Synapses are highly specialized structures that interconnect neurons to form functional networks dedicated to neuronal communication. During brain development, synapses undergo activity-dependent rearrangements leading to both structural and functional changes. Many molecular processes are involved ...
ORGANISM(S): Rattus norvegicus (Rat) 
2021-11-25 | PXD028804 | Pride
Post-translational modification Developping rat brain Synapse Sumo 
TranscriptomicsThe MOF-containing NSL complex associates globally with housekeeping genes, but activates only a defined subset
This SuperSeries is composed of the following subset Series: GSE30989: MOF-containing NSL complex specifically binds promoters of most, but stimulates only a specific subset of, housekeeping genes (ChIP-chip dataset) GSE30990: MOF-containing NSL complex specifically binds promoters of most, but stim...
ORGANISM(S): Drosophila melanogaster 
2011-10-28 | E-GEOD-30991 | biostudies-arrayexpress
UnknownCharacterization of Gtf1p, the connector subunit of yeast mitochondrial tRNA-dependent amidotransferase.
Not available
S-EPMC3190888 | biostudies-literature
UnknownPhysician Training Related to Environmental Hazards near Ash Superfund Sites.
Not available
S-EPMC8568049 | biostudies-literature
TranscriptomicsComparative profiling in 13 muscle disease groups
Summary: Genetic disorders of muscle cause muscular dystrophy, and are some of the most common inborn errors of metabolism. Muscle also rapidly remodels in response to training and innervation. Muscle weakness and wasting is important in such conditions as aging, critical care medicine, space flig...
ORGANISM(S): Homo sapiens 
2005-10-14 | E-GEOD-3307 | biostudies-arrayexpress
TranscriptomicsArray profiling of dystrophin-deficient mice with a secondary glycosylation defect
A deletion in the CMAH gene in humans occurred approximately 3.5 million years ago. This resulted in the inactivation of the CMP-Neu5Ac hydroxylase enzyme, and hence, in the specific deficiency in N-glycolylneuraminic acid (Neu5Gc), a form of sialic acid, in all modern humans. Although there is evid...
ORGANISM(S): Mus musculus 
2010-07-31 | E-GEOD-16438 | biostudies-arrayexpress
TranscriptomicsEuglycemic agent-mediated hypothalamic transcriptomic manipulation in the N171-82Q model of Huntington's disease is related to their physiological efficacy
Our aim was to find an effective treatment for the dysfunction in energy regulation and hypothalamic integrity occurring in many HuntingtonM-bM-^@M-^Ys disease (HD) patients and mouse models. HD is a neurodegenerative disease caused by an expanded CAG repeat and is characterized by mutant huntingtin...
ORGANISM(S): Mus musculus 
2012-10-05 | E-GEOD-39586 | biostudies-arrayexpress
TranscriptomicsTGF-β1 Accelerates Dendritic Cell Differentiation from Common Dendritic Cell Progenitors (CDPs) and Directs Subset Specification Towards Conventional Dendritic Cells
Dendritic cells (DCs) in lymphoid tissue comprise conventional DCs (cDCs) and plasmacytoid DCs (pDCs) that develop from common DC progenitors (CDPs). CDPs are Flt3+c-kitintM-CSFR+ and reside in bone marrow. Here we describe a two-step culture system that recapitulates DC development from c-kithiFlt3...
ORGANISM(S): Mus musculus 
2010-10-04 | E-GEOD-22432 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Medicago truncatula genes in roots in response to high (2 mM) and low (20 ?M) phosphate concentrations
Expression of Medicago truncatula genes in roots in response to high (2 mM) and low (20 µM) phosphate concentrations.
ORGANISM(S): Medicago truncatula 
2005-06-30 | E-MEXP-238 | biostudies-arrayexpress
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