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ProteomicsPPM1D mutations are oncogenic drivers of de novo Diffuse Midline Glioma formation
Khadka P, Reitman ZJ, Lu S, Buchan G, Gionet G, Dubois F, Carvalho DM, Shih J, Zhang S, Greenwald N, Zack T, Shapira O, Pelton K, Hartley R, Bear H, Georgis Y, Jarmale S, Melanson R, Bonano K, Schoolcraft K, Miller PG, Condurat AL, Gonzalez E, Qian K, Morin E, Langhnoja J, Lupien L, Rendo V, Digiaco...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) Mus Musculus (ncbitaxon:10090) 
2021-11-17 | MSV000088404 | MassIVE
MetabolomicsFeatures of acute COVID-19 associated with post-acute sequelae of SARS-CoV-2 phenotypes: results from the IMPACC study
Post-acute sequelae of SARS-CoV-2 (PASC) is a significant public health concern. We describe Patient Reported Outcomes (PROs) on 590 participants prospectively assessed from hospital admission for COVID-19 through one year after discharge. Modeling identified 4 PRO clusters based on reported deficit...
2024-01-12 | MTBLS850 | MetaboLights
TranscriptomicspCREB-dependent transcriptional activation is a mediator of molecular neuroadaptations induced by methamphetamine self-administration in the rat dorsal striatum
Neuroplastic changes in the dorsal striatum participate in the transition from casual drug use to habitual and compulsive drug taking. These alterations might also play a critical role in the development of methamphetamine (METH) addiction. Nevertheless, the molecular substrates that underlie habitu...
ORGANISM(S): Rattus norvegicus 
2012-05-31 | E-GEOD-38223 | biostudies-arrayexpress
UnknownBlockchain-enabled immutable, distributed, and highly available clinical research activity logging system for federated COVID-19 data analysis from multiple institutions.
Not available
S-EPMC10198529 | biostudies-literature
TranscriptomicsTranscription profiling of human muscle tissue in patients with inflammatory myopathies
Molecular profiles of muscle tissue in patients with inflammatory myopathies
ORGANISM(S): Homo sapiens 
2007-09-20 | E-GEOD-281 | biostudies-arrayexpress
TranscriptomicsTargeted RNA-seq (TempO-Seq) of temporal concentration responses to drug exposures in PHH and HepaRG cells
For the purpose of mechanism-based risk assessment, we investigated temporal concentration-dependent responses in cultures of PHH and HepaRG cells exposed to three drugs, acetaminophen (APAP), cyclosporine A (CSA) and valproic acid (VPA), that have a high liability for drug-induced liver injury. To ...
ORGANISM(S): synthetic construct 
2024-03-01 | E-MTAB-12668 | biostudies-arrayexpress
TranscriptomicsViral Expression and Molecular Profiling in Liver Tissue versus Microdissected Hepatocytes in Hepatitis B Virus - Associated Hepatocellular Carcinoma
The molecular mechanisms whereby hepatitis B virus (HBV) induces hepatocellular carcinoma (HCC) remain elusive. We used genomic and molecular techniques to investigate host-virus interactions by mapping the entire liver of patients with HCC. We compared the gene signature of whole liver tissue (WLT)...
ORGANISM(S): Homo sapiens 
2014-12-22 | E-GEOD-55092 | biostudies-arrayexpress
TranscriptomicshmU-Seq Reveals Genome-Wide Distribution of 5-Hydroxymethyluracil via Selective Enzymatic and Chemical Labeling
5-Hydroxymethyluridine (5hmU) is an epigenetic thymine modification and occurs across diverse organisms. 5hmU has been linked to cancer development and therapy resistance, yet its precise biological functions remain poorly understood. Genomic profiling of 5hmU is severely hindered by cross-reactivit...
ORGANISM(S): Mus musculus 
2026-09-30 | E-MTAB-17088 | biostudies-arrayexpress
UnknownGut microbiome perturbation, antibiotic resistance, and Escherichia coli strain dynamics associated with international travel: a metagenomic analysis.
Not available
S-EPMC10680401 | biostudies-literature
TranscriptomicsTargeted RNA-seq (TempO-Seq) of temporal concentration responses to cosmetic ingredients exposures in PHH and HepaRG cells
For the purpose of mechanism-based risk assessment, we investigated temporal concentration-dependent responses in cultures of PHH and HepaRG cells exposed to three cosmetics ingredients, 2,7-naphthalenediol (NPT), triclosan (TCS) and butylated hydroxytoluene (BHT), that are suspected to have liver i...
ORGANISM(S): synthetic construct 
2024-03-01 | E-MTAB-12677 | biostudies-arrayexpress
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