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TranscriptomicsEffect of fbw7 deletion in mouse pancreatic ducts
The adult pancreas is capable of limited regeneration after injury, but has no defined stem cell population. The cell types and molecular signals that govern the production of new pancreatic tissue are not well understood. Here we show that inactivation of the SCF-type E3 ubiquitin ligase substrate ...
ORGANISM(S): Mus musculus 
2014-08-07 | E-GEOD-58969 | biostudies-arrayexpress
TranscriptomicsNuRD-mediated gene repression in mouse embryonic stem cells
To obtain a global view of NuRD-mediated transcriptional regulation, gene expression profiles of wild-type and Mbd3-null ES cells were compared by microarray analysis. In the absence of Mbd3, which encodes a core structural component of NuRD, the complex does not form and embryonic development stall...
ORGANISM(S): Mus musculus 
2012-03-13 | E-MTAB-889 | biostudies-arrayexpress
GenomicsNuRD-mediated gene repression in mouse embryonic stem cells
To obtain a global view of NuRD-mediated transcriptional regulation, gene expression profiles of wild-type and Mbd3-null ES cells were compared by microarray analysis. In the absence of Mbd3, which encodes a core structural component of NuRD, the complex does not form and embryonic development stall...
ORGANISM(S): Mus musculus 
2012-03-13 | E-MTAB-888 | biostudies-arrayexpress
UnknownTFEB-mediated lysosomal biogenesis and lysosomal drug sequestration confer resistance to MEK inhibition in pancreatic cancer.
Not available
S-EPMC7066197 | biostudies-literature
TranscriptomicsTranscriptional profiling of Mbd3 knockout and wild-type embryonic stem cells
RNA-seq was performed for transcriptional analysis of wild-type mouse embryonic stem (ES) cells and an Mbd3 knockout line. Mbd3 is a core component of the Nucleosome Remodeling and Deacetylation (NuRD) complex, which modulates transcriptional heterogeneity and pluripotency gene expression in ES cell...
ORGANISM(S): Mus musculus 
2012-05-04 | E-MTAB-997 | biostudies-arrayexpress
Transcriptomicsc-JUN REPROGRAMS SCHWANN CELLS OF INJURED NERVES TO GENERATE A REPAIR CELL ESSENTIAL FOR REGENERATION
The striking PNS regenerative response to injury rests on the plasticity of adult Schwann cells and their ability to transit between differentiation states, a highly unusual feature in mammals. Using mice with inactivation of Schwann cell c-Jun, we show that the injury response involves c-Jun depen...
ORGANISM(S): Mus musculus 
2012-06-13 | E-GEOD-38693 | biostudies-arrayexpress
TranscriptomicsRNA-Seq of Lgr6 positive and negative cells in mouse mammary gland
Lgr6-positive cells have been shown to label stem/progenitors cells in several tissues including tongue and skin. However their role in mammary gland has never been investigated. Here we used Lgr6-eGFP-IRES-CreER2 mice to isolate and characterize Lgr6-positive population in mammary gland of 5-week o...
ORGANISM(S): Mus musculus 
2016-09-06 | E-GEOD-75648 | biostudies-arrayexpress
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