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TranscriptomicsRNA sequencing of luminal breast cancer patient-derived xenografts (PDX) library to capture tumor heterogeneity and explore the mechanisms of resistance to CDK4/6 inhibitors
Combining CDK4/6 inhibitors (CDK4/6i) with endocrine therapy has proven clinically effective and represents now the first-line treatment for advanced Luminal Breast Cancer (LBC) patients. However, resistance to CDK4/6i almost invariably arises in these patients, emphasising the critical need to comp...
ORGANISM(S): Homo sapiens 
2024-11-18 | E-MTAB-14085 | biostudies-arrayexpress
TranscriptomicsGenetic characterization of p27Kip1 and stathmin role in controlling cell proliferation in vivo
The CDK inhibitor p27Kip1 is a critical regulator of cell cycle progression, but the mechanisms by which p27Kip1 controls cell proliferation in vivo are still not fully elucidated. We recently demonstrated that the microtubule destabilizing protein stathmin is a relevant p27Kip1binding partner invol...
ORGANISM(S): Mus musculus 
2015-04-01 | E-GEOD-60078 | biostudies-arrayexpress
TranscriptomicsRadiotherapy-induced miR expression influences breast cancer recurrence formation.
The act of surgery strongly stimulated breast cancer cell growth in mice. Local irradiation of wounded breast efficiently prevented wounded-induced breast cancer cell growth. These modifications were linked to miR modulation both in human specimens and in the mouse model, in vivo. The most significa...
ORGANISM(S): Homo sapiens 
2017-01-03 | E-MTAB-1562 | biostudies-arrayexpress
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