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ProteomicsIdentification of signalling pathways downstream of ARHGEF17
Somatic DNA copy number variations (CNVs) are prevalent in cancer and can drive cancer progression albeit with often uncharacterized roles in altering cell signaling states. We developed a computational approach to predict regulators of signaling from the integrative analysis of genomic and proteomi...
ORGANISM(S): Homo sapiens (Human) 
2021-04-06 | PXD021031 | Pride
Tem4 
UnknownAstroglia-mediated neuroinflammation as a putative mechanism of neurological outcomes in COVID-19? Insights from a Brazilian cohort.
Not available
S-EPMC12547199 | biostudies-literature
ProteomicsIdentifications of protein kinase A substrates with quantitative phosphoproteomics and primary-sequence based scoring.(forskolin)
Protein kinase A (PKA) is a serine/threonine kinase who plays essential roles in the complex signalling pathways. To better understand the functionalities, it is necessary to elucidate direct interplays between PKA and their substrates in living system. In order to screen them in a high-throughput m...
ORGANISM(S): Homo Sapiens (human) 
2018-02-14 | PXD005922 | JPOST Repository
ProteomicsIdentifications of protein kinase A substrates with quantitative phosphoproteomics and primary-sequence based scoring.(H-89)
Protein kinase A (PKA) is a serine/threonine kinase who plays essential roles in the complex signalling pathways. To better understand the functionalities, it is necessary to elucidate direct interplays between PKA and their substrates in living system. In order to screen them in a high-throughput m...
ORGANISM(S): Homo Sapiens (human) 
2018-02-15 | PXD005925 | JPOST Repository
UnknownZika virus vertical transmission induces neuroinflammation and synapse impairment in brain cells derived from children born with Congenital Zika Syndrome.
Not available
S-EPMC11297915 | biostudies-literature
Proteomics,MultiomicsProtein phosphorylation evolution across 18 fungal species
Protein phosphorylation evolution across 18 fungal species. For each species whole cell extracts were digested separately with trypsin and LysC. Each digest was IMAC enriched and analyzed by LC-MS/MS in technical triplicate on an LTQ Orbitrap Velos using a 120min method. Data was searched against th...
ORGANISM(S): S. Cerevisiae, S. Paradoxus, S. Mikatae, S. Kudriavzevii, S. Bayanus, N. Castellii, C. Glabrata, V. Polyspora, Z. Rouxii, K. Lactis, L. Kluyveri, L. Thermotolerans, L. Waltii, K. Pastoris, M. Guilliermondii, C. Albicans, S. Stipitis, S. Pombe 
2015-12-18 | MSV000079428 | MassIVE
TranscriptomicsRNA-seq time-course of Calu-3 cells infected with SARS-CoV-2 early-lineage and Alpha variant viruses
Emergence of SARS-CoV-2 variants of concern (VOCs), including the globally successful Alpha (B.1.1.7) variant, suggests viral adaptation to enhance human-to-human transmission. Although much effort has focused on characterisation of spike changes, Alpha mutations outside spike likely contribute to a...
ORGANISM(S): Homo sapiens 
2021-12-31 | E-MTAB-11275 | biostudies-arrayexpress
ProteomicsGenomic determinants of protein abundance variation in colorectal cancer cell lines
Assessing the impact of genomic alterations on protein networks is fundamental in identifying the mechanisms that shape cancer heterogeneity. We have used isobaric labelling to characterize the proteomic landscapes of 50 colorectal cancer cell lines and to decipher the functional consequences of som...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
MSV000081528 | MassIVE
ProteomicsA SARS-CoV-2-Human Protein-Protein Interaction Map Reveals Drug Targets and Potential Drug-Purposing
An outbreak of the novel coronavirus SARS-CoV-2, the causative agent of COVID-19 respiratory disease, has infected over 170,000 people since the end of 2019, killed over 7,400, and caused worldwide social and economic disruption. SARS-CoV-2 infection has a mortality rate of 3.4% among confirmed case...
ORGANISM(S): Severe Acute Respiratory Syndrome Coronavirus 2 (ncbitaxon:2697049) Homo Sapiens (ncbitaxon:9606) 
2020-03-24 | MSV000085144 | MassIVE
ProteomicsThe Global Phosphorylation Landscape of SARS-CoV-2 Infection
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of the coronavirus disease 2019 (COVID-19) pandemic, has infected over 3 million people worldwide and caused over 200,000 deaths since it emerged in late 2019. There is an urgent need to develop therapies that can limi...
ORGANISM(S): Chlorocebus Aethiops (ncbitaxon:9534) 
2020-07-15 | MSV000085759 | MassIVE
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