Sort   by:  
 Page size 
TranscriptomicsDetermining the impact of alternative splicing events on transcriptome dynamics
Background The complete sequencing of the human genome and its subsequent analysis revealed a predominant role for alternative splicing in the generation of proteome diversity. Splice switching oligonucleotides (SSOs) are a powerful and specific tool to experimentally control alternative splicing of...
ORGANISM(S): Homo sapiens 
2008-10-02 | E-GEOD-9851 | biostudies-arrayexpress
Transcriptomicsp53 independent TAF6delta target genes.
To elucidate the impact of TAF6d on cell death and gene expression, here we have employed modified antisense oligonucleotides to enforce expression of endogenous TAF6d. The induction of endogenous TAF6d triggered apoptosis in tumor cell lines, including cells devoid of p53. Microarray experiments re...
ORGANISM(S): Homo sapiens 
2008-06-26 | E-GEOD-10795 | biostudies-arrayexpress
TranscriptomicsEBER2 RNA-induced transcriptome changes identify cellular processes likely targeted during Epstein Barr Virus infection.
Little is known about the physiological role of the EBER1 and 2 nuclear RNAs during Epstein Barr viral infection. The cellular transcription response to EBER2 expression using the wild-type and an internal deletion mutant was determined. Significant changes in gene expression patterns were observed....
ORGANISM(S): Homo sapiens 
2008-10-02 | E-GEOD-11093 | biostudies-arrayexpress
UnknownTracing the first steps of American sturgeon pioneers in Europe.
Not available
S-EPMC2527320 | biostudies-literature
TranscriptomicsTarget genes associated to siRNA mediated repression of Pea3 and Erm transcription factors in mammary cancerous cells
Pea3 and Erm are transcription factors belonging to the ETS family which are involved in tumorigenesis, particularly mammary oncogenesis. To elucidate the mechanism of Pea3/Erm induced tumorigenesis in mouse mammary cancerous MMT cells (ATCC CCL-51), we have down-regulated Pea3 or Erm expression in ...
ORGANISM(S): Mus musculus 
2008-08-01 | E-GEOD-6588 | biostudies-arrayexpress
TranscriptomicsTAF6 orchestrates transcription programs and apoptosis in the absence of p53
The decision of metazoan cells to live or undergo programmed cell death hinges on the balance between the levels of pro- versus anti-apoptotic gene products. The general RNA polymerase II (Pol II) transcription factor, TFIID, plays a central role in the regulation of gene expression through its core...
ORGANISM(S): Homo sapiens 
2010-11-27 | E-GEOD-8752 | biostudies-arrayexpress
TranscriptomicsInterferon and ribavirin treatment in a rhesus macaque model of novel Middle East respiratory syndrome coronavirus (MERS-CoV) infection (hCoV-EMC)
Microarray analysis of lungs (right lower lobe) on day 3 post-infection with MERS-CoV with and without treatment beginning 8 h post-infection with intravenous type I interferon (IFN) and ribavirin (RBV). Dosages are as follows: IFN a2b 5 million IU/kg s.c. q8, RBV loading dose 50mg/kg i.v.; RBV mai...
ORGANISM(S): Macaca mulatta 
2013-09-06 | E-GEOD-47957 | biostudies-arrayexpress
TranscriptomicsRhesus macaque model of hCoV-EMC respiratory infection
Microarray analysis of peripheral blood mononuclear cells (PBMCs), lungs, and lung lesions collected over the course of hCoV-EMC infection of 6 rhesus macaques. 6 rhesus macaques were infected intratracheally with hCoV-EMC. PBMCs were collected at days 0, 1, 3, and 6, and lungs were collected from s...
ORGANISM(S): Macaca mulatta 
2013-08-29 | E-GEOD-44542 | biostudies-arrayexpress
TranscriptomicsRole for HA and the viral RNA polymerase complex in the virulence of the 1918 influenza virus
The goal of this experiment was to examine the biological properties of reassortant viruses between the 1918 virus and a contemporary human H1N1 virus to determine the role of hemagglutinin (HA) and the viral RNA polymerase complex of 1918 virus toward pathogenesis and abberant host responses in mic...
ORGANISM(S): Mus musculus 
2013-02-23 | E-GEOD-44595 | biostudies-arrayexpress
TranscriptomicsEarly transcriptional programming links progression to hepatitis C virus-induced severe liver disease in transplant patients
This study determined key transcriptional signatures associated with HCV recurrence and eventual development of severe liver disease in infected transplant patient liver biopsies over time following transplant. We identified molecular signatures associated with severe fibrosis and liver injury prior...
ORGANISM(S): Homo sapiens 
2012-02-10 | E-GEOD-34798 | biostudies-arrayexpress
Sort   by:  
 Page size