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TranscriptomicsHigh-throughput sequencing of AGO-immunoprecipitating miRs in human senescent fibroblast WI-38
In humans, there are four Ago proteins (Ago1M-bM-^@M-^S4) and AGO1- and 2 were previously implicated in TGS induced by exogenous siRNAs and microRNAs (miRs) directed against gene promoter transcripts via promotion of changes in histone covalent modifications and DNA methylation. Not-with-standing, m...
ORGANISM(S): Homo sapiens 
2011-12-17 | E-GEOD-34494 | biostudies-arrayexpress
TranscriptomicsTranscriptomic datat of senescence WI-38 cell
Senescence in WI-38 cell context was induce by RASv12 over expression Cellular senescence is a permanent cell cycle arrest that is triggered by cancer- initiating or promoting events in mammalian cells and is now considered a major tumour suppressor mechanism. Here, we did a transcriptomic analysis...
ORGANISM(S): Homo sapiens 
2011-11-16 | E-GEOD-33710 | biostudies-arrayexpress
TranscriptomicsChip-chip from WI-38 human fibroblast with Argonaute antibody
In humans, there are four Ago proteins (Ago1–4) and AGO1- and 2 were previously implicated in TGS induced by exogenous siRNAs and microRNAs (miRs) directed against gene promoter transcripts via promotion of changes in histone covalent modifications and DNA methylation. Not-with-standing, many mechan...
ORGANISM(S): Homo sapiens 
2011-11-30 | E-GEOD-33998 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Arabidopsis strain with T-DNA insertions in the HAF2 gene
T-DNA insertions in the HAF2 gene are characterised. The mutation of the gene induced production of pale young leaves. Genetic analysis showed that HAF2 is required for both phytochrome and cryptochrome signalling. Accordingly, light-inducible gene expression and CAB2 promoter activity were affected...
ORGANISM(S): Arabidopsis thaliana 
2004-10-05 | E-MEXP-178 | biostudies-arrayexpress
TranscriptomicsQuantitative analysis of proliferative and Ras-induced senescent human primary fibroblasts transcriptomes
The goals of this study is to analyse transcriptionnal changes in senescent cells and to compare them with ChIPseq data for several histones marks and proteins of the SUMO machinery mRNA profiling of proliferative versus Ras-induced senescent humain primary fibroblasts 5 days post-infection
ORGANISM(S): Homo sapiens 
2013-07-24 | E-GEOD-42212 | biostudies-arrayexpress
GenomicsGenome wide occupancy of SUMO machinery in proliferative and Ras-induced senescent human primary fibroblasts
Transcription factors represent one of the largest groups of proteins regulated by SUMO, and their modification has generally been correlated with transcriptional repression. However, as most of the studies focus on specific sumoylated transcriptional regulators, the distribution and global role of ...
ORGANISM(S): Homo sapiens 
2013-07-24 | E-GEOD-42211 | biostudies-arrayexpress
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