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MetabolomicsSCP4-STK35/PDIK1L complex is a dual phospho-catalytic signaling dependency in acute myeloid leukemia
Acute myeloid leukemia (AML) cells rely on phospho-signaling pathways to gain unlimited proliferation potential. Here, we used domain-focused CRISPR screening to identify the nuclear phosphatase SCP4 as a dependency in AML, yet this enzyme is dispensable in normal hematopoietic progenitor cells. Usi...
2025-05-29 | MTBLS3707 | MetaboLights
MetabolomicsA metabolic dependency for host isoprenoids in the obligate intracellular pathogen Rickettsia parkeri underlies a sensitivity for the statin class of host-targeted therapeutics
Gram-negative bacteria in the order Rickettsiales are obligate intracellular parasites that cause human diseases such typhus and spotted fever. They have evolved a dependence on essential nutrients and metabolites from the host cell as a consequence of extensive genome streamlining. However, it rema...
2019-10-31 | MTBLS846 | MetaboLights
ProteomicsQuantitative In Vivo Proteomics of Metformin Response in Liver Reveals AMPK-Dependent and -Independent Signaling Networks
Metformin is the front-line treatment for type 2 diabetes worldwide. It acts via effects on glucose and lipid metabolism in metabolic tissues, leading to enhanced insulin sensitivity. Despite significant effort, the molecular basis for metformin response remains poorly understood, with a limited nu...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2019-10-07 | MSV000084429 | MassIVE
ProteomicsUrine protein composition of common bottlenose dolphins (Tursiops truncatus) in the Gulf of Mexico, USA
Urinary proteins provide valuable insights into renal health, with implications spanning human and domestic animal veterinary medical research. However, the field of marine mammal medicine lacks comprehensive studies on urine protein composition. This research aimed to fill this gap by 1) selecting ...
ORGANISM(S): Tursiops truncatus (Atlantic bottle-nosed dolphin) (Delphinus truncatus) 
2024-08-01 | PXD054283 | Pride
Lc-msms Urine Common bottlenose dolphin 
MetabolomicsImprovement of prediction ability by integrating multi-omic datasets in barley

BACKGROUND: Genomic prediction (GP) based on single nucleotide polymorphisms (SNP) has become a broadly used tool to increase the gain of selection in plant breeding. However, using predictors that are biologically closer to the phenotypes such as transcriptome and metabolome may...

2022-03-18 | MTBLS1561 | MetaboLights
UnknownMET amplification identifies a small and aggressive subgroup of esophagogastric adenocarcinoma with evidence of responsiveness to crizotinib.
Not available
S-EPMC3255989 | biostudies-literature
ProteomicsPreferential phosphorylation on old histones during early mitosis in human cells
How histone posttranslational modifications (PTMs) are inherited through cell cycle remains poorly understood. Canonical histones are made in the S phase of cell cycle. Combining mass spectrometry-based technologies and stable isotope labeling by amino acids in cell culture (SILAC), we interrogate t...
ORGANISM(S): Homo sapiens (Human) 
2016-06-01 | PXD003709 | Pride
Mass spectrometry Mitosis Histone modifications Cell cycle Histone phosphorylation 
UnknownEvaluation of Residency Applicant Preferences for Continuing Virtual Interviews: A National Database Analysis.
Not available
S-EPMC11838067 | biostudies-literature
UnknownSomatic mutations predict poor outcome in patients with myelodysplastic syndrome after hematopoietic stem-cell transplantation.
Not available
S-EPMC4207878 | biostudies-literature
UnknownEffect of Maternal Obesity and Preconceptional Weight Loss on Male and Female Offspring Metabolism and Olfactory Performance in Mice.
Not available
S-EPMC6566604 | biostudies-literature
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