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TranscriptomicsPeturbation of PICALM Levels Alters Cellular Cholesterol Metabolism
PICALM (Phosphatidyl Inositol Clathrin Assembly Lymphoid Myeloid protein) is a ubiquitously expressed protein that plays a role in clathrin-mediated endocytosis. PICALM also affects the internalization of SNAREs and modulates macroautophagy. Chromosomal translocations that result in the fusion of PI...
ORGANISM(S): Mus musculus 
2015-06-17 | E-GEOD-64855 | biostudies-arrayexpress
TranscriptomicsLXR activation in RAW264.7 mouse macrophages expressing LXRalpha.
To identify novel LXR target genes, we conducted transcriptional profiling studies using RAW264.7 cells ectopically expressing LXRalpha Total RNA was isolated from RAW264.7 macrophages ectopically expressing LXRalpha as described in Venkateswaran et al. (2000); PNAS 97, 12097-12102. Cells were cult...
ORGANISM(S): Mus musculus 
2009-08-01 | E-GEOD-17088 | biostudies-arrayexpress
UnknownPro-inflammatory macrophage activation does not require inhibition of oxidative phosphorylation
Not available
S-SCDT-10_1038-S44319-024-00351-Y | biostudies-other
UnknownCoenzyme A activates TLR4 and enhances alternative macrophage activation in line with MyD88 agonism
Not available
S-SCDT-10_1038-S44319-026-00925-Y | biostudies-other
UnknownCalculation of ATP production rates using the Seahorse XF Analyzer
Not available
S-SCDT-10_15252-EMBR_202256380 | biostudies-other
TranscriptomicsLimiting cholesterol biosynthetic flux engages type I IFN signaling in a STING-dependent manner
Cellular lipid requirements are achieved through a combination of biosynthesis and import programs. Using isotope tracer analysis, we show that type I interferon (IFN) signaling rapidly shifts the balance of these programs by decreasing synthesis and increasing import of cholesterol and long chain f...
ORGANISM(S): Homo sapiens 
2015-12-10 | E-GEOD-73942 | biostudies-arrayexpress
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