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TranscriptomicsGenome-wide peripheral blood transcriptome analysis of Arab female Lupus and Lupus nephritis
Genome-wide alternative splice analysis of RNA from lupus and its severe form lupus nephritis We aimed to explore the genome-wide peripheral blood transcriptome of lupus (SLE) and its severe form lupus nephritis (LN) cases compared to healthy subjects (HC) using high density Affymetrix Human Exon1.0...
ORGANISM(S): Homo sapiens 
2016-01-06 | E-GEOD-62764 | biostudies-arrayexpress
TranscriptomicsGlobal changes in gene expression during sub-zero acclimation of three Arabidopsis thaliana accessions
During cold acclimation plants increase their freezing tolerance in response to low non-freezing temperatures. This is accompanied by many physiological, biochemical and molecular changes that have been extensively investigated. In addition, many cold acclimated plants become more freezing tolerant ...
ORGANISM(S): Arabidopsis thaliana 
2014-03-12 | E-GEOD-55835 | biostudies-arrayexpress
TranscriptomicsscRNA-seq analysis of enriched CD4+ T cells from lung tissues after single or combined AIT treatment strategies with AhR agonist 10-Cl-BBQ in a murine model of OVA-induced allergic airway inflammation (AAI)
Allergen-specific immunotherapy (AIT) is able to restore immune tolerance to allergens in allergic patients. However, some patients do not or only poorly respond to current treatment protocols. Therefore, there is a need for deeper mechanistic insights and further improvement of treatment strategies...
ORGANISM(S): Mus musculus 
2024-05-06 | E-MTAB-14030 | biostudies-arrayexpress
UnknownProteomics Profiling and Risk of New-Onset Atrial Fibrillation: Framingham Heart Study.
Not available
S-EPMC6475036 | biostudies-literature
TranscriptomicsmiRNA array after p63 knock down in human squamous cell carcinoma
A central challenge in human cancer therapy is the identification of pathways that control tumor cell survival and chemosensitivity in the absence of functional p53. The p53-related transcription factors p63 and p73 exhibit distinct, p53-independent roles in development and cancer: p73 promotes geno...
ORGANISM(S): Homo sapiens 
2010-11-23 | E-GEOD-25524 | biostudies-arrayexpress
GenomicsGenome-wide Runx2 occupancy in prostate cancer cells suggests a role in regulating secretion.
Runx2 is a metastatic transcription factor (TF) increasingly expressed during prostate cancer (PCa) progression. Using PCa cells conditionally expressing Runx2, we previously identified Runx2-regulated genes with known roles in epithelial-mesenchymal transition, invasiveness, angiogenesis, extracel...
ORGANISM(S): Homo sapiens 
2011-11-29 | E-GEOD-33889 | biostudies-arrayexpress
TranscriptomicsRole of epigenetic modifiers on the bovine fibroblast innate immune response
The innate immune signaling pathway plays a crucial role in the recognition and early response to pathogens associated with disease. Genetic analysis has been unable to completely account for individual variability in the strength of the innate immune response. The aim of this study was to determine...
ORGANISM(S): Bos taurus 
2014-01-01 | E-GEOD-50405 | biostudies-arrayexpress
TranscriptomicsIscR of Rhodobacter sphaeroides functions as repressor of genes for iron-sulphur metabolism and represents a new type of iron-sulphur binding protein
Iron-sulphur (Fe-S) clusters are ensembles of iron and sulphide centres. They are found in all life forms and are important components of many enzymes involved in diverse cellular processes, including respiration, DNA synthesis or gene regulation. However, the increase in oxygen after the emergence...
ORGANISM(S): Rhodobacter sphaeroides 2.4.1 
2015-02-03 | E-GEOD-65537 | biostudies-arrayexpress
TranscriptomicsMicroarray analysis of RNase I-deficient Escherichia coli versus wild-type BW25113
The present study investigated the role(s) of RNase I (encoded by the rna gene) in Escherichia coli by comparative gene expression analysis of an rna mutant and the isogenic wild-type E. coli strain BW25113. The transcriptomic analysis aims to provide mechanistic insight into aberrant phenotypes obs...
ORGANISM(S): Escherichia coli 
2020-01-04 | E-MTAB-6095 | biostudies-arrayexpress
UnknownIs adjuvant chemotherapy of benefit for postmenopausal women who receive endocrine treatment for highly endocrine-responsive, node-positive breast cancer? International Breast Cancer Study Group Trials VII and 12-93.
Not available
S-EPMC3589110 | biostudies-literature
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