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GenomicsGenome-wide maps of histone modifications in Arabidopsis thaliana
Histone acetylation and methylation regulate gene expression in eukaryotes, but their effects on the transcriptome of a multicellular organism and on the transcriptomic divergence between species are still poorly understood. Here we present the first genome-wide 1-bp resolution maps of histone acety...
ORGANISM(S): Arabidopsis thaliana 
2011-02-02 | E-GEOD-22276 | biostudies-arrayexpress
TranscriptomicsExploring the mechanism of C4 photosynthetic differentiation through a unified comparative analysis of maize and rice leaf transcriptomes
Maize and rice are the two most economically important grass crops and utilize distinct forms of photosynthesis to fix carbon: C4 and C3 respectively. Relative to C3 photosynthesis, C4 photosynthesis reduces photorespiration and affords higher water and nitrogen use efficiencies under hot arid condi...
ORGANISM(S): Zea mays 
2014-10-12 | E-GEOD-54274 | biostudies-arrayexpress
ProteomicsVvinifera L. - Shoot, NSAF (Crameretal,bmcplantbiol2013)
abundance based on NSAF, Interaction consistency score: 11.1, Coverage: 8
ORGANISM(S): 29760 
2013-00-00 | 1323817045 | PAXDB
ProteomicsVvinifera L. - Shoot, NSAF (Crameretal,bmcplantbiol2013)
abundance based on NSAF, Interaction consistency score: 9.5, Coverage: 8
ORGANISM(S): 29760 
2013-00-00 | 3382834283 | PAXDB
TranscriptomicsBrassinosteroid, gibberellin, and phytochrome impinge on a common transcription module in Arabidopsis
Brassinosteroid (BR) and gibberellin (GA) promote many similar developmental responses in plants; but their relationship remains unclear. Here we show that BR and GA act interdependently through a direct interaction between the BR-activated BZR1 and GAinactivated DELLA transcription regulators. GA p...
ORGANISM(S): Arabidopsis thaliana 
2012-06-25 | E-GEOD-35408 | biostudies-arrayexpress
GenomicsGenome-Wide Characterization of Pancreatic Adenocarcinoma Patients Using Next Generation Sequencing

In this study, we whole genome sequenced tumor/normal pairs from three pancreatic adenocarcinoma patients to separately characterize each patient with respect to somatic alterations. For 2 patients for whom tumor RNA was available, we also performed RNA sequencing to evaluate gene expression chan...

phs000550.v1.p1 | EGA
UnknownA phase 1 trial of the HDAC inhibitor AR-42 in patients with multiple myeloma and T- and B-cell lymphomas.
Not available
S-EPMC5489371 | biostudies-literature
TranscriptomicsDeletion of the Mammalian INDY Homologue in Mice Mimics Aspects of Dietary Restriction and Protects Against Diet and Age-Induced Adiposity and Insulin Resistance
Reduction in expression of the INDY gene in Drosophila melanogaster and Caenorhabditis elegans prolongs life span, and in D. melanogaster augments mitochondrial biogenesis in a manner akin to caloric restriction. However, the cellular mechanism by which INDY does this is unknown. In order to examine...
ORGANISM(S): Mus musculus 
2011-08-03 | E-GEOD-29984 | biostudies-arrayexpress
UnknownGenome-wide characterization of pancreatic adenocarcinoma patients using next generation sequencing.
Not available
S-EPMC3468610 | biostudies-literature
TranscriptomicsGene expression of LNCaP cells grown in polyethlene glycol-based hydrogels alone (monocultures) and grown with human osteoblasts as tissue engineered bone (co-culture) with the presence of synthetic androgen, R1881
Analysis of LNCaP cell molecular differences in monocultures and in co-cultures in the presence of R1881. Human osteoblast molecular signatures were also identified from the tissue engineered bone monocultures. LNCaP cells molecular profile was altered by co-culturing with human osteoblasts compared...
ORGANISM(S): Homo sapiens 
2014-05-13 | E-GEOD-44143 | biostudies-arrayexpress
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