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TranscriptomicsExpression data from human pluripotent stem cells and differentiated cells treated with pluripotent-specific inhibitors
The use of human pluripotent stem cells (hPSCs) in cell therapy is hindered by the tumorigenic risk from residual undifferentiated cells. Here we performed a high-throughput screen of over 52,000 small molecules, and identified 15 highly selective cytotoxic inhibitors of hPSCs (PluriSIns). Cellular ...
ORGANISM(S): Homo sapiens 
2013-01-22 | E-GEOD-37040 | biostudies-arrayexpress
UnknownThe Chromatin Regulator ZMYM2 Restricts Human Pluripotent Stem Cell Growth and Is Essential for Teratoma Formation.
Not available
S-EPMC7724477 | biostudies-literature
TranscriptomicsSex dependent gene expression in human pluripotent stem cells
During early development before gonadal differentiation, sex chromosomes are the main difference between males and females. We examined any genetically driven sex dimorphisms in human pluripotent stem cells focusing on Y chromosome contribution. In order to understand the consequence of these dif...
ORGANISM(S): Homo sapiens 
2014-06-18 | E-GEOD-58591 | biostudies-arrayexpress
UnknownIdentifying regulators of parental imprinting by CRISPR/Cas9 screening in haploid human embryonic stem cells.
Not available
S-EPMC8602306 | biostudies-literature
GenomicsDNAseq analysis of a genome-wide loss-of-function CRISPR/Cas9 library in haploid human embryonic stem cells transfected with a methylated construct containing the FXS-related mutation upstream to an EGFP reporter gene
DNAseq analysis of a genome-wide loss-of-function CRISPR/Cas9 library in haploid human embryonic stem cells transfected with a methylated construct containing the FXS-related mutation upstream to an EGFP reporter gene
PRJNA756781 | ENA
TranscriptomicsDifferentiation of human parthenogenetic pluripotent stem cells reveals multiple tissue and isoform specific imprinted transcripts
Parental imprinting results in a monoallelic parent-of-origin dependent gene expression. However, many imprinted genes identified by differential methylation do not exhibit complete monoallelic expression. Previous studies demonstrated a complex tissue-dependent expression patterns for some imprint...
ORGANISM(S): Homo sapiens 
2016-07-03 | E-GEOD-65002 | biostudies-arrayexpress
Genomicsena-DATASET-HU-17-07-2017-20:03:05:530-176 - samples
This dataset includes deep coverage (>60x) whole exomes of 15 human embryonic stem cell lines. Genomic DNA was purified and fragmented using the Illumina Nextera system for library preparation and sequenced using 150bp paired-end reads. Sequencing reads were aligned to the hg19 reference genome usin...
EGAD00001003446 | EGA
GenomicsBiological insights from the whole genome sequences of human embryonic stem cell lines
Human embryonic stem cells (hESCs) are a powerful tool for the study of human development and can form the basis of cellular disease models or therapies. However, the genetic make-up and stability of hESCs has not been systematically studied at a genome-wide level with single nucleotide resolution. ...
EGAS00001002400 | EGA
GenomicsDAC for Human Stem Sell Sequencing
Data Access Committee EGAC00001000642
EGAC00001000642 | EGA
TranscriptomicsGlobal indiscriminate methylation in cell-specific gene promoters following reprogramming into human induced pluripotent stem cells
Genome wide DNA methylation profiling of somatic and pluripotent cells from different lineages (mesoderm, endoderm and parthenogenetic germ cells) The Illumina Infinium 27k Human DNA methylation Beadchip v1.2 was used to obtain DNA methylation profiles across approximately 27,000 CpGs. Samples inclu...
ORGANISM(S): Homo sapiens 
2014-05-01 | E-GEOD-52238 | biostudies-arrayexpress
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