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TranscriptomicsFOXM1 Cistrome Predicts Breast Cancer Metastatic Outcome Better Than FOXM1 Expression Levels or Tumor Proliferation Index [RNA-Seq]
FOXM1 is a key transcription factor regulating cell cycle progression, DNA damage response, and a host of other hallmark cancer features, but the role of the FOXM1 cistrome in driving estrogen receptor-positive (ER+) vs. ER- breast cancer clinical outcomes remains undefined. Chromatin immunoprecipit...
ORGANISM(S): Homo sapiens 
2015-10-26 | E-GEOD-73370 | biostudies-arrayexpress
GenomicsFOXM1 Cistrome Predicts Breast Cancer Metastatic Outcome Better Than FOXM1 Expression Levels or Tumor Proliferation Index [ChIP-Seq]
FOXM1 is a key transcription factor regulating cell cycle progression, DNA damage response, and a host of other hallmark cancer features, but the role of the FOXM1 cistrome in driving estrogen receptor-positive (ER+) vs. ER- breast cancer clinical outcomes remains undefined. Chromatin immunoprecipit...
ORGANISM(S): Homo sapiens 
2015-10-26 | E-GEOD-72977 | biostudies-arrayexpress
TranscriptomicsDistinct genetic alterations occur in ovarian tumor cells selected for combined resistance to carboplatin and docetaxel
Background: Current protocols for the treatment of ovarian cancer include combination chemotherapy with a platinating agent and a taxane. However, many patients experience relapse of their cancer and the development of drug resistance is not uncommon, making successful second line therapy difficult ...
ORGANISM(S): Homo sapiens 
2013-07-22 | E-GEOD-39337 | biostudies-arrayexpress
TranscriptomicsExon profiling of human Gray (LBNL) breast cancer cell lines
Exon array profiling of Gray (LBNL) breast cancer cell lines
ORGANISM(S): Homo sapiens 
2010-12-01 | E-MTAB-181 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of breast cancer distant metastasis based on outcome over time and identification of pathway activities of late relapse
Previous reports have described the use of microarrays to assess the molecular classification of human breast cancers and defined new subgroups based on gene expression that are relevant to patient management through their ability to predict metastatic relapse and survival relapse. However, differen...
ORGANISM(S): Homo sapiens 
2013-08-01 | E-MTAB-949 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human patients recruited to the paclitaxel arm of the CTCR-OV01 study, pre-treatment individuals with ovarian cancer
All patients with suspected ovarian cancer (Raised CA 125 and a complex pelvic mass in a perimenopausal woman) were radiologically staged using CT scan and a chest x-ray. Patients with evidence of intra-abdominal metastasis and/or malignant pleural effusion were approached for entry to the study. Ti...
ORGANISM(S): Homo sapiens 
2008-06-16 | E-GEOD-9455 | biostudies-arrayexpress
TranscriptomicsMYC is a major determinant of mitotic cell fate
Purpose: To determine global gene expression changes following siRNA knockdown of Myc, Kcnk1, and Snta1 compared to non-targeting siRNAs or mock-transfected cells Methods: Total RNA was processed using the Illumina TruSeq Stranded mRNA Sample Preparation Kit according to manufacturer’s protocol. Gen...
ORGANISM(S): Homo sapiens 
2015-07-13 | E-GEOD-68219 | biostudies-arrayexpress
GenomicsEGAD00000000119
Genotypes from cell lines derived from breast carcinoma tissue
EGAD00000000119 | EGA
GenomicsAssessment of genomic copy number alterations in breast cancer
The aim of this study was to assess genomic copy number alterations in a panel of breast cancer cell lines. These data were used to identify common aberrations associated with breast cancer, and also to identify aberrations associated with response to therapeutic compounds.
EGAS00000000059 | EGA
GenomicsBreast Cancer Cell Line Data Access Committee
Access to data is available by emailing application to the data access committee and will be granted to qualified investigators for appropriate use.
EGAC00000000015 | EGA
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