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TranscriptomicsHigh-throughput pyrosequencing of endogenous small RNAs from Arabidopsis thaliana wild-type and ddm1 mutant.
DNA methylation is essential for silencing transposable elements and some genes in higher eukaryotes, implying that this modification must be tightly controlled. However, accidental changes in DNA methylation can be transmitted through mitosis, as in cancer, or meiosis, leading to epiallelic variati...
ORGANISM(S): Arabidopsis thaliana 
2009-02-02 | E-GEOD-13419 | biostudies-arrayexpress
TranscriptomicsNID2 and HOXA9 promoter hypermethylation as biomarkers to prevent and detect Oral Cavity Squamous Cell Carcinoma
Differentially methylated oral squamous cell carcinoma (OSCC) biomarkers, identified in-vitro and validated in well-characterized surgical specimens, have shown poor clinical correlation in cohorts with different risk profiles. To overcome this lack of relevance we used the HumanMethylation27 BeadCh...
ORGANISM(S): Homo sapiens 
2013-02-13 | E-GEOD-28217 | biostudies-arrayexpress
TranscriptomicsChanges in the Pattern of DNA Methylation Associate with Twin Discordance in SLE
This is the first high-throughput analysis of DNA methylation in autoimmune diseases. We have used a cohort of MZ twins discordant for three diseases whose clinical signs often overlap: systemic lupus erythematosus (SLE), rheumatoid arthritis and dermatomyositis. Only MZ twins discordant for SLE fea...
ORGANISM(S): Homo sapiens 
2009-11-16 | E-GEOD-19033 | biostudies-arrayexpress
TranscriptomicsRegulation of DNA methylation by CK2-mediated phosphorylation of DNMT3A (Beadchip)
DNA methylation is a central epigenetic modification that has essential roles in cellular processes including chromatin structure, gene regulation, development and disease. The de novo DNA methyltransferases are responsible for the generation of genomic methylation patterns, but the underlying mecha...
ORGANISM(S): Homo sapiens 
2014-07-17 | E-GEOD-26164 | biostudies-arrayexpress
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