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MetabolomicsCE-MS Metabolomic and LC-MS Proteomic Analyses of Breast Cancer Exosomes Reveal Alterations in Purine and Carnitine Metabolism

A nano sheath-flow capillary electrophoresis mass spectrometry (CE-MS) system with electrospray ionization was used to profile cationic metabolite cargo in exosomes secreted by non-tumorigenic MCF-10A and tumorigenic MDA-MB-231 breast epithelial cells. CE-MS-based metabolomics revealed increased ...

2024-11-14 | MTBLS11190 | MetaboLights
ProteomicsProteomics Profiling of Breast Cell Line-derived Extracellular Vesicles
Membrane-derived extracellular vesicles, referred to as microvesicles (MVs), have been proposed to participate in several cancer diseases. In this study, MV fractions were isolated by differential ultracentrifugation from a metastatic breast cancer (BC) cell line MDA-MB-231 and a non-cancerous breas...
ORGANISM(S): Homo sapiens (Human) 
2021-01-25 | PXD023505 | Pride
Human Proteomics Cell lines Extracellular vesicles 
ProteomicsProteomic Analysis of Rana sylvatica Reveals Differentially Expressed Proteins in Liver in Response to Anoxia, Dehydration or Freezing Stress
Ectothermic animals that live in seasonally cold regions are adapted to seasonal variation and specific environmental conditions. During the winter, some amphibians hibernate terrestrially and encounter a limited amount of environmental water, deficient oxygen, and extremely low temperatures that ca...
ORGANISM(S): Lithobates sylvaticus 
2024-08-10 | PXD050540 | Pride
Lc-ms Proteomics 
ProteomicsPhosphoproteomic analysis of breast cancer-derived extracellular vesicles reveals disease-specific phosphorylated enzymes
Small membrane-derived extracellular vesicles have been proposed to participate in several cancer diseases, including breast cancer. We performed phosphoproteomic analysis of breast cancer-derived small extracellular vesicles (sEVs) to provide insight into the molecular and cellular regulatory mecha...
ORGANISM(S): Homo sapiens (Human) 
2022-02-28 | PXD030424 | Pride
  small extracellular vesicles Breast cancer  phosphoproteomics 
ProteomicsSurface Proteome of Extracellular Vesicles and Correlation Analysis for Identification of Breast Cancer Biomarkers
Breast cancer (BC) is the second leading cause of death in Canadian women. Despite this, non-invasive early detection methods for BC have yet to be developed. Cells release various types of extracellular vesicles (EVs) as intercellular signals into biofluids, such as blood, reflecting the physiologi...
ORGANISM(S): Homo sapiens (Human) 
2024-05-21 | PXD048074 | Pride
Surface proteins Breast cancer Proteomics Biomarkers Extracellular vesicles 
ProteomicsLysine acetolome of breast cancer-derived small extracellular vesicles reveals specific acetylation pattern for metabolic enzymes
Cancer-derived small extracellular vesicles have been proposed as promising potential biomarkers for diagnosis and prognosis of breast cancer (BC). We performed a proteomic study of lysine acetylation of breast cancer-derived small extracellular vesicles (sEVs) to understand the potential role of th...
ORGANISM(S): Homo sapiens (Human) 
2023-07-20 | PXD040413 | Pride
Protein acetylation Small extracellular vesicles Breast cancer 
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