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ProteomicsIntegrative proteomic and transcriptomic profiling identifies unique and shared functions of oncogenic KRAS and RIT1
Lo A, Holmes K, Mundt F, Moorthi S, Fung I, Fereshetian S, Watson J, Carr SA, Mertins P, Berger A. Aberrant activation of RAS oncogenes is a prevalent event in lung adenocarcinoma, with somatic mutation of KRAS occurring in ~30% of tumors. Recently, we identified somatic mutation of the RAS-family G...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2020-04-03 | MSV000085225 | MassIVE
UnknownPrevalence and outcomes of patients developing heparin-induced thrombocytopenia during extracorporeal membrane oxygenation.
Not available
S-EPMC9359525 | biostudies-literature
TranscriptomicsDetermination and Inference of Eukaryotic Transcription Factor Sequence Specificity
The DNA sequence preferences of the vast majority of eukaryotic transcription factors (TFs) are unknown. Using an approach designed to broadly sample both DNA-binding domain types and eukaryotic clades, we have determined DNA-binding motifs for 1,033 TFs from 131 diverse eukaryotes, encompassing 54...
ORGANISM(S): synthetic construct 
2014-08-01 | E-GEOD-53348 | biostudies-arrayexpress
TranscriptomicsAcetyl-CoA metabolism by ACSS2 regulates neuronal histone acetylation and long-term memory [RNA-seq]
Metabolic production of acetyl-CoA has been linked to histone acetylation and gene regulation, however the mechanisms are largely unknown. We show that the metabolic enzyme acetyl-CoA synthetase 2 (ACSS2) is a critical and direct regulator of histone acetylation in neurons and of long-term mammalian...
ORGANISM(S): Mus musculus 
2017-05-01 | E-GEOD-76853 | biostudies-arrayexpress
GenomicsAcetyl-CoA metabolism by ACSS2 regulates neuronal histone acetylation and long-term memory [ChIP-seq]
Metabolic production of acetyl-CoA has been linked to histone acetylation and gene regulation, however the mechanisms are largely unknown. We show that the metabolic enzyme acetyl-CoA synthetase 2 (ACSS2) is a critical and directchum regulator of histone acetylation in neurons and of long-term mamma...
ORGANISM(S): Mus musculus 
2017-05-01 | E-GEOD-76850 | biostudies-arrayexpress
UnknownWhat can claims data tell us about risk factors and survival of patients with hepatocellular carcinoma? Insights from a German population-based study.
Not available
S-EPMC12750458 | biostudies-literature
UnknownTreatment gaps and survival outcomes of hepatocellular carcinoma: insights from a nationwide, claims-based study.
Not available
S-EPMC12547113 | biostudies-literature
TranscriptomicsEvaluation of methods for modeling transcription factor sequence specificity
Genomic analyses often involve scanning for potential transcription-factor (TF) binding sites using models of the sequence specificity of DNA binding proteins. Many approaches have been developed to model and learn a protein’s binding specificity by representing sequence motifs, including the gaps a...
ORGANISM(S): synthetic construct 
2012-12-13 | E-GEOD-42864 | biostudies-arrayexpress
TranscriptomicsTranslocations Activating IRF4 Identify a Subtype of Germinal-Center-Derived B-cell Lymphoma Affecting Predominantly Children and Young Adults
Background: Germinal center B-cell (GCB) lymphomas are common in children and adults. The prognosis strongly depends on age. Subgroups of GCB-lymphomas are characterized by chromosomal translocations affecting immunoglobulin (IG) loci leading to oncogene deregulation. Methods: Novel IG translocation...
ORGANISM(S): Homo sapiens 
2011-06-24 | E-GEOD-22470 | biostudies-arrayexpress
UnknownEarly mortality in atezolizumab/bevacizumab for HCC is associated with impaired liver function and alterations of systemic immunity.
Not available
S-EPMC12861967 | biostudies-literature
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