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TranscriptomicsLong-range bidirectional transcription is a general feature of developmental gene promoters in mammals
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2014-01-01 | E-GEOD-44578 | biostudies-arrayexpress
TranscriptomicsGenome-Wide Expression Profiling Deciphers Host Responses Altered during Dengue Shock Syndrome and Reveals the Role of Innate Immunity in Severe Dengue
Background Deciphering host responses contributing to dengue shock syndrome (DSS), the life-threatening form of acute viral dengue infections, is required to improve both the differential prognosis and the treatments provided to DSS patients, a challenge for clinicians. Methodology/Principal Findin...
ORGANISM(S): Homo sapiens 
2010-07-21 | E-GEOD-17924 | biostudies-arrayexpress
GenomicsLong-range bidirectional transcription is a general feature of developmental gene promoters in mammals (ChIP-Seq 1)
Recent studies have revealed a myriad of non-coding transcripts in different organisms. For instances, the presence of short bidirectional transcripts is a hallmark of active promoters in mammals, while upstream non-coding transcripts can be detected at most expressed genes in conditions where the R...
ORGANISM(S): Mus musculus 
2014-01-01 | E-GEOD-44577 | biostudies-arrayexpress
GenomicsLong-range bidirectional transcription is a general feature of developmental gene promoters in mammals (ChIP-Seq 2)
Recent studies have revealed a myriad of non-coding transcripts in different organisms. For instances, the presence of short bidirectional transcripts is a hallmark of active promoters in mammals, while upstream non-coding transcripts can be detected at most expressed genes in conditions where the R...
ORGANISM(S): Mus musculus 
2014-01-01 | E-GEOD-45014 | biostudies-arrayexpress
TranscriptomicsLong-range bidirectional transcription is a general feature of developmental gene promoters in mammals (RNA-Seq 2)
Recent studies have revealed a myriad of non-coding transcripts in different organisms. For instances, the presence of short bidirectional transcripts is a hallmark of active promoters in mammals, while upstream non-coding transcripts can be detected at most expressed genes in conditions where the R...
ORGANISM(S): Mus musculus 
2014-01-01 | E-GEOD-44575 | biostudies-arrayexpress
TranscriptomicsLong-range bidirectional transcription is a general feature of developmental gene promoters in mammals (RNA-Seq 1)
Recent studies have revealed a myriad of non-coding transcripts in different organisms. For instances, the presence of short bidirectional transcripts is a hallmark of active promoters in mammals, while upstream non-coding transcripts can be detected at most expressed genes in conditions where the R...
ORGANISM(S): Mus musculus 
2014-01-01 | E-GEOD-44232 | biostudies-arrayexpress
GenomicsH3K4 tri-methylation provides an epigenetic signature of active enhancers
Combinations of post-translational histone modifications shape the chromatin landscape during cell development in eukaryotes. However, little is known about the modifications exactly delineating functionally engaged regulatory elements. For example, although histone H3 lysine 4 mono-methylation (H3K...
ORGANISM(S): Mus musculus 
2014-03-07 | E-GEOD-55635 | biostudies-arrayexpress
TranscriptomicsHuman Neonate CD8-T cells are biased towards innate immunity defense mechanisms
To understand better the nature of the poor response of human neonates to intracellular pathogens, we evaluated the transcriptome of neonates as compared to adult naïve CD8-T cells. A specific transcription signature of the neonatal cells was found, characterized by a lower expression of signallin...
ORGANISM(S): Homo sapiens 
2016-07-25 | E-GEOD-61570 | biostudies-arrayexpress
TranscriptomicsIdentification of transcript dysregulation in patients with Autism Spectrum Disorders
In order to unveil the molecular mechanisms at play during the development of autistic brains, we studied cells that are representative of the very early stages of ontogenesis, namely stem cells. We used nasal olfactory stem cells that are readily accessible and can be biopsied safely. We recruited ...
ORGANISM(S): Homo sapiens 
2014-11-22 | E-GEOD-63524 | biostudies-arrayexpress
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