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UnknownPooled Analysis of Long-Term Survival Data From Phase II and Phase III Trials of Ipilimumab in Unresectable or Metastatic Melanoma.
Not available
S-EPMC5089162 | biostudies-literature
GenomicsNucleosome map of the IMR90 fibroblast cell line
We produced a map of nucleosome positions in IMR90 by sequencing the ends of MNase-digested chromatin fragments. IMR90 cells were grown in culture, about 1E6 cells were isolated and digested using micrococcal nuclease (MNase). Mononucleosomes were gel-selected and fragment ends were sequenced using ...
ORGANISM(S): Homo sapiens 
2011-04-01 | E-GEOD-21823 | biostudies-arrayexpress
TranscriptomicsAndrogen dependent gene expression profiling of the urogenital sinus
Cancer cells differentiate along specific lineages that largely determine their clinical and biologic behavior. Distinct cancer phenotypes from different cells and organs likely result from unique gene expression repertoires established during lineage commitment in the embryo and maintained after ma...
ORGANISM(S): Mus musculus 
2008-12-03 | E-GEOD-12077 | biostudies-arrayexpress
GenomicsINSPIRE - Investigator-initiated Phase 2 Study of Pembrolizumab Immunological Response in Metastatic Solid Tumors
Whole exome and RNA sequencing source data for: Clouthier, D.L., Lien, S.C., Yang, S.Y.C. et al. An interim report on the investigator-initiated phase 2 study of pembrolizumab immunological response evaluation (INSPIRE). j. immunotherapy cancer 7, 72 (2019). https://doi.org/10.1186/s40425-019-0541-...
EGAS00001003280 | EGA
MetabolomicsCholesterol dysregulation contributes to hematopoietic failure in parn-mutant zebrafish with implications for dyskeratosis congenita
Germline mutations in PARN cause dyskeratosis congenita (DC), an inherited bone marrow failure syndrome characterized by multilineage cytopenia and progression to myeloid disease. The mechanisms underlying this malignant transformation have not been fully elucidated. Here we show, using a loss-of-fu...
2026-09-29 | MTBLS15863 | MetaboLights
UnknownComparison of diabetes to other prognostic predictors among patients referred for cardiac stress testing: A contemporary analysis from the REFINE SPECT Registry.
Not available
S-EPMC9085969 | biostudies-literature
TranscriptomicsGene expression in a Highly Tumorigenic Cells (HTC) purified from Urothelial Cancer
We used DNA microarrays to compare RNA transcript expression from distinct cell populations sorted by FACS with an antibody against the 67Kd laminin receptor (67LR), and showing distinct tumorigenicity in vivo. Sorted cells were derived by digesting xenografted sw 780 tumors into single cell suspens...
ORGANISM(S): Homo sapiens 
2009-05-28 | E-GEOD-16255 | biostudies-arrayexpress
TranscriptomicsTransgenic NUP98-HOXA9 Zebrafish Embryos: Unactivated ('lGl') vs. Cre-activated ('NHA9')
Transcriptional profiling of zebrafish embryos at 28 hours post fertilization, comparing control 'unactivated' Tg(spi1::lox-eGFP-lox::NHA9) embryos with experimental 'Cre-activated' Tg(spi1::NHA9) embryos. Goal was to determine the effects of expressing NUP98-HOXA9 oncogene on global and blood cell-...
ORGANISM(S): Danio rerio 
2014-10-30 | E-GEOD-62793 | biostudies-arrayexpress
GenomicsRegions of Focal DNA Hypermethylation and Long-Range Hypomethylation in Colorectal Cancer Coincide with Nuclear Lamina-Associated Domains
Extensive changes in DNA methylation are common in cancer and may contribute to oncogenesis through transcriptional silencing of tumor suppressor genes. Genome-scale studies have yielded important insights into these changes, but have focused on CpG islands or gene promoters. We used whole-genome bi...
ORGANISM(S): Homo sapiens 
2011-09-26 | E-GEOD-32399 | biostudies-arrayexpress
GenomicsGenome-wide mapping of nucleosome positioning and DNA methylation within Individual DNA molecules
DNA methylation and nucleosome positioning work together to generate chromatin structures that regulate gene expression. Nucleosomes are typically mapped using nuclease digestion requiring significant amounts of material and varying enzyme concentrations. We have developed a method (NOMe-seq) that u...
ORGANISM(S): Homo sapiens 
2012-09-12 | E-GEOD-40770 | biostudies-arrayexpress
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