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TranscriptomicsmicroRNA profiles of immune cells and their exosomes
Microarray analysis of exosomal miRNAs vs the miRNAs of their respective donor cells. To determine the miRNA repertoires of exosomes secreted by immune cells, we isolated exosomes from cell supernatants of the Raji B cell line, the Jurkat-derived J77 T cell line, and primary dendritic cells (DCs) de...
ORGANISM(S): Homo sapiens 
2011-03-17 | E-GEOD-27997 | biostudies-arrayexpress
TranscriptomicsIncreased levels of aneuploidy and deregulation of ploidy controlling genes are associated with maintained cultures of hMSC
Human mesenchymal stem cells (hMSC) are being successfully evaluated for the treatment of a wide range of pathological conditions, including graft versus host disease (GVHD), bone and cartilage degeneration, complex fistula and myocardial infarction. Many of these clinical trials use hMSC, which hav...
ORGANISM(S): Homo sapiens 
2012-10-30 | E-GEOD-39250 | biostudies-arrayexpress
TranscriptomicsCell senescence abrogates the immunomodulatory therapeutic potential of human mesenchymal stem cells
In this study, we have addressed how cellular senescence influences the immunomodulatory potential of human mesenchymal stem cells (hMSCs). We induced cell senescence in a panel of bone marrow-derived hMSC samples by means of gamma-irradiation, and performed both gene expression and miRNA microarray...
ORGANISM(S): Homo sapiens 
2014-06-01 | E-GEOD-48662 | biostudies-arrayexpress
TranscriptomicsmiR-335 regulates cell migration and differentiation in human mesenchymal stem cells
Human mesenchymal stem cells (hMSC) have an extensive potential for clinical applications in cell therapy. However, very little is known of the specific molecular regulatory mechanisms that control the therapeutical properties of these cells. We aimed to identify microRNAs (miRNAs) that could be inv...
ORGANISM(S): Homo sapiens 
2010-05-06 | E-GEOD-19232 | biostudies-arrayexpress
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