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TranscriptomicsMolecular phenotyping of multiple mouse strains under metabolic challenge uncovers Elovl2 as a novel regulator of glucose-induced insulin secretion
Defective insulin secretion by pancreatic β cells underlies the development of type 2 diabetes (T2D). High fat diet-fed mice are commonly used to study diabetes progression, but studies are usually limited to a single strain, such as C57Bl/6J. Here, we use a systems biology approach to integrate la...
ORGANISM(S): Mus musculus 
2017-04-28 | E-GEOD-78183 | biostudies-arrayexpress
UnknownSoft Tissue and Uterine Leiomyosarcoma.
Not available
S-EPMC5759317 | biostudies-literature
TranscriptomicsIdentification of target genes of myostatin loss-of-function in the muscle of bovine fetuses
Myostatin is a highly conserved Transforming Growth Factor beta family member which negatively regulates muscle development. Double-muscled (DM) cattle have a loss-of-function mutation in their myostatin gene responsible for a hypermuscular phenotype mainly due to hyperplasia. Thus these animals rep...
ORGANISM(S): Bos taurus 
2010-07-01 | E-GEOD-5456 | biostudies-arrayexpress
TranscriptomicsIdentification of novel markers of beef sensory quality and muscle growth potential
The transcriptome of bovine Longissimus thoracis muscles from 15- and 19-month-old Charolais young bulls were analyzed in order to identify genes whose expression level was associated to beef quality scores, in particular to tenderness, juiciness and flavor, and to muscle growth potential. The expre...
ORGANISM(S): Bos taurus 
2007-08-17 | E-GEOD-5561 | biostudies-arrayexpress
UnknownA prospective observational study for justification, safety, and efficacy of a third dose of mRNA vaccine in patients receiving maintenance hemodialysis.
Not available
S-EPMC8628628 | biostudies-literature
TranscriptomicsTEAD4 occupied genes in differentiated C2C12 myoblasts
The TEAD (1-4) transcription factors comprise the conserved TEA/ATTS DNA binding domain recognising the MCAT element in the promoters of muscle-specific genes. Despite extensive genetic analysis, the function of TEAD factors in muscle differentiation has proved elusive due to redundancy amongst the ...
ORGANISM(S): Mus musculus 
2011-08-21 | E-GEOD-29208 | biostudies-arrayexpress
TranscriptomicsHigh-Resolution Profiling of Novel Transcribed Regions During Rat Spermatogenesis
Mammalian spermatogenesis is a complex and highly orchestrated combination of processes in which male germline proliferation and differentiation result in the production of mature spermatozoa. If recent genome-wide studies have contributed to the in-depth analysis of the male germline protein-coding...
ORGANISM(S): Rattus norvegicus 
2014-06-01 | E-GEOD-48321 | biostudies-arrayexpress
UnknownRandomized Phase II Trial of Seribantumab in Combination With Paclitaxel in Patients With Advanced Platinum-Resistant or -Refractory Ovarian Cancer.
Not available
S-EPMC5562430 | biostudies-literature
TranscriptomicsThe dynamic transcriptional profile of sertoli cells during the progression of spermatogenesis
Sertoli cells (SCs), the only somatic cells within seminiferous tubules, associate intimately with developing germ cells. They not only provide physical and nutritional support but also secrete factors essential to the complex developmental processes of germ cell proliferation and differentiation. T...
ORGANISM(S): Mus musculus 
2015-08-25 | E-GEOD-59698 | biostudies-arrayexpress
ModelsMAPK Cancer Cell Fate Network
The Mitogen-Activated Protein Kinase (MAPK) network consists of tightly interconnected signalling pathways involved in diverse cellular processes, such as cell cycle, survival, apoptosis and differentiation. Although several studies reported the involvement of these signalling cascades in cancer der...
7984 | Cell Collective
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